Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 5/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 3/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | FABP3 | P05413 | 1/20 | 0.32 |
| ▸ | FABP4 | P15090 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | ATM | Q13315 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21625485 | 1.00 | NLRP3 (0.35) | NLRP3LNPEPPKMPOLBL3MBTL1 | |
| SCHEMBL21625479 | 0.78 | NLRP3 (0.39) | NLRP3SMN1; SMN2ATM | |
| SCHEMBL21127855 | 0.75 | DRD4 (0.31) | NLRP3KDM4EALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL24975328 | 0.75 | DRD4 (0.37) | KDM4EALDH1A1SMN1; SMN2LMNAHPGD | |
| SCHEMBL28538564 | 0.74 | LNPEP (0.33) | LNPEPL3MBTL1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL21625481 | 0.73 | GAA (0.36) | LNPEPPKMKDM4EALDH1A1MAPK1 | |
| SCHEMBL28913746 | 0.73 | L3MBTL1 (0.36) | NLRP3LNPEPPKMPOLBL3MBTL1 | |
| SCHEMBL17344774 | 0.71 | NOS3 (0.33) | — | |
| SCHEMBL21625487 | 0.70 | HTT (0.45) | POLBKDM4EALDH1A1TSHRMAPK1 | |
| SCHEMBL21637172 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4093509-A1 | SULFONIMIDAMIDE COMPOUNDS AS NLRP3 MODULATORS | F. Hoffmann-La Roche AG (CH) | 2022-11-30 | — | — | EP | disclosed |