Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 11/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 8/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | CYP8B1 | Q9UNU6 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31454781 | 1.00 | CYP3A4 (0.44) | CYP3A4CYP2C9CYP2C19CYP19A1CYP11B1 | |
| SCHEMBL3949948 | 1.00 | CYP3A4 (0.44) | CYP3A4CYP2C9CYP2C19CYP19A1CYP11B1 | |
| SCHEMBL3264782 | 1.00 | CYP3A4 (0.44) | CYP3A4CYP2C9CYP2C19CYP19A1CYP11B1 | |
| SCHEMBL8812022 | 1.00 | CYP3A4 (0.44) | CYP3A4CYP2C9CYP2C19CYP19A1CYP11B1 | |
| SCHEMBL2346412 | 1.00 | CYP3A4 (0.44) | CYP3A4CYP2C9CYP2C19CYP19A1CYP11B1 | |
| SCHEMBL17777817 | 1.00 | CYP3A4 (0.44) | CYP3A4CYP2C9CYP2C19CYP19A1CYP11B1 | |
| SCHEMBL7989762 | 1.00 | CYP3A4 (0.44) | CYP3A4CYP2C9CYP2C19CYP19A1CYP11B1 | |
| SCHEMBL8574154 | 1.00 | CYP3A4 (0.44) | CYP3A4CYP2C9CYP2C19CYP19A1CYP11B1 | |
| SCHEMBL3955770 | 1.00 | CYP3A4 (0.44) | CYP3A4CYP2C9CYP2C19CYP19A1CYP11B1 | |
| SCHEMBL29858099 | 1.00 | CYP3A4 (0.44) | CYP3A4CYP2C9CYP2C19CYP19A1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 199 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3915981-B1 | METHOD FOR PREPARATION OF EFINACONAZOLE IN IONIC LIQUID MEDIUM | DAEBONG LS CO LTD (KR) | 2024-04-03 | — | — | EP | claimed |
| US-20220127245-A1 | METHOD FOR PREPARATION OF EFINACONAZOLE IN IONIC LIQUID MEDIUM | DAEBONG LS CO., LTD. (KR) | 2022-04-28 | — | — | US | claimed |
| EP-3915981-A1 | METHOD FOR PREPARATION OF EFINACONAZOLE IN IONIC LIQUID MEDIUM | Daebong LS Co., Ltd. (KR) | 2021-12-01 | — | — | EP | claimed |
| CN-113330006-A | Novel preparation method of efinaconazole by taking ionic liquid as medium | 大峰LS株式会社 | 2021-08-31 | — | — | CN | claimed |
| WO-2021060948-A1 | METHOD FOR PREPARATION OF EFINACONAZOLE IN IONIC LIQUID MEDIUM | 대봉엘에스 주식회사 | 2021-04-01 | — | — | WO | claimed |
| CN-106918672-B | Method for measuring related substances in efinaconazole raw material medicine and preparation thereof by using HPLC | 中美华世通生物医药科技（武汉）有限公司 | 2021-02-09 | — | — | CN | claimed |
| CN-107759565-B | Preparation method of 1-triazole-2-butanol derivative | 苏州旺山旺水生物医药有限公司 | 2020-10-23 | — | — | CN | claimed |
| US-10626102-B2 | Process for the synthesis of efinaconazol | PROCOS S.P.A. (IT) | 2020-04-21 | — | — | US | claimed |
| US-10479776-B2 | Process for the preparation of Efinaconazole | LUPIN LIMITED (IN) | 2019-11-19 | — | — | US | claimed |
| EP-3397628-B1 | PROCESS FOR THE SYNTHESIS OF EFINACONAZOL | PROCOS SPA (IT) | 2019-09-18 | — | — | EP | claimed |
| EP-2612859-B1 | METHOD FOR PRODUCING 1-TRIAZOLE-2-BUTANOL DERIVATIVE | KAKEN PHARMA CO LTD (JP) | 2015-09-30 | — | — | EP | claimed |
| US-8871942-B2 | Process for producing 1-triazole-2-butanol derivatives | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 2014-10-28 | — | — | US | claimed |
| EP-2612859-A1 | METHOD FOR PRODUCING 1-TRIAZOLE-2-BUTANOL DERIVATIVE | Kaken Pharmaceutical Co., Ltd. (JP) | 2013-07-10 | — | — | EP | claimed |
| US-20130150586-A1 | PROCESS FOR PRODUCING 1-TRIAZOLE-2-BUTANOL DERIVATIVES | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 2013-06-13 | — | — | US | claimed |
| EP-1282084-B9 | METHOD FOR PREPARING PYRIMIDONE DERIVATIVES WITH ANTIFUNGAL ACTIVITY | URIACH & CIA SA J (ES) | 2005-03-02 | — | — | EP | claimed |
| US-6653475-B2 | Coupling a compound with pyrimidone intermediate | J. URIACH & CIA, S.A. (ES) | 2003-11-25 | — | — | US | claimed |
| EP-1282084-B1 | METHOD FOR PREPARING PYRIMIDONE DERIVATIVES WITH ANTIFUNGAL ACTIVITY | URIACH & CIA SA J (ES) | 2003-09-17 | — | — | EP | claimed |
| US-20030064986-A1 | Method for preparing pyrimidone derivatives with antifungal activity | ALLERGAN PHARMACEUTICALS INTERNATIONAL LIMITED (IE) | 2003-04-03 | — | — | US | claimed |
| EP-1282084-A2 | METHOD FOR PREPARING PYRIMIDONE DERIVATIVES WITH ANTIFUNGAL ACTIVITY | J. Uriach & Cia. S.A. (ES) | 2003-02-05 | — | — | EP | claimed |
| EP-1231210-A2 | Azole antifungal agents, processes for the preparation thereof, and intermediates | Eisai Co., Ltd. (JP) | 2002-08-14 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030064986-A1 | Method for preparing pyrimidone derivatives with antifungal activity | TYMP, UMPS, DPM1 | CYP3A4 93/4885CYP2C9 128/4885CYP2C19 25/4885 |
| US-20220127245-A1 | METHOD FOR PREPARATION OF EFINACONAZOLE IN IONIC LIQUID MEDIUM | CYP3A5, NEFM, IL5 | CYP3A4 5/4885CYP2C9 24/4885CYP2C19 17/4885 |
| US-10626102-B2 | Process for the synthesis of efinaconazol | CYP3A4, EFHD2, CYP4F3 | CYP3A4 1/4885CYP2C9 20/4885CYP2C19 7/4885 |
| US-20130150586-A1 | PROCESS FOR PRODUCING 1-TRIAZOLE-2-BUTANOL DERIVATIVES | CACNA1I, MED1, ADH1A | CYP3A4 304/4885CYP2C9 715/4885CYP2C19 1130/4885 |
| US-10479776-B2 | Process for the preparation of Efinaconazole | CYP3A4, ERG28, CYP4Z1 | CYP3A4 1/4885CYP2C9 47/4885CYP2C19 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.