Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 4/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 3/20 | 1.00 |
| ▸ | NFKB2 | Q00653 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | RELA | Q04206 | 3/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | PPP1CA | P62136 | 2/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 1/20 | 1.00 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.78 |
| ▸ | VCP | P55072 | 1/20 | 0.78 |
| ▸ | NPC1 | O15118 | 3/20 | 0.76 |
| ▸ | HTT | P42858 | 2/20 | 0.76 |
| ▸ | RAB9A | P51151 | 2/20 | 0.76 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.75 |
| ▸ | MBD2 | Q9UBB5 | 2/20 | 0.72 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.72 |
| ▸ | KCNN1 | Q92952 | 2/20 | 0.72 |
| ▸ | KCNN2 | Q9H2S1 | 2/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7678939 | 0.90 | MAPT (0.81) | SMN1; SMN2MAPTNFKB1NFKB2KMT2A | |
| Bromide SCHEMBL7673197 | 0.88 | MAPT (0.79) | SMN1; SMN2MAPTNFKB1NFKB2KMT2A | |
| SCHEMBL1887374 | 0.88 | VCP (1.00) | SMN1; SMN2MAPTNFKB1NFKB2KMT2A | |
| SCHEMBL13803792 | 0.88 | MAPT (0.78) | SMN1; SMN2MAPTNFKB1NFKB2KMT2A | |
| SCHEMBL1890717 | 0.86 | MAPT (0.74) | SMN1; SMN2MAPTNFKB1NFKB2KMT2A | |
| SCHEMBL29602125 | 0.85 | MAPT (0.74) | SMN1; SMN2MAPTNFKB1NFKB2KMT2A | |
| SCHEMBL6368825 | 0.85 | MAPT (0.74) | SMN1; SMN2MAPTNFKB1NFKB2KMT2A | |
| SCHEMBL23657798 | 0.84 | MAPT (0.72) | SMN1; SMN2MAPTNFKB1NFKB2KMT2A | |
| SCHEMBL13390238 | 0.84 | MBD2 (1.00) | SMN1; SMN2MAPTNFKB1NFKB2KMT2A | |
| SCHEMBL30060152 | 0.84 | MBD2 (1.00) | SMN1; SMN2MAPTNFKB1NFKB2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170066758-A1 | SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF CANCERS, INCLUDING HEPATOCELLULAR CARCINOMA, AND AS INHIBITORS OF HEPATITIS VIRUS REPLICATION | INSTITUTE FOR HEPATITIS AND VIRUS RESEARCH | 2017-03-09 | — | — | US | claimed |
| US-20140249154-A1 | SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF CANCERS, INCLUDING HEPATOCELLULAR CARCINOMA, AND AS INHIBITORS OF HEPATITIS VIRUS REPLICATION | BARUCH S. BLUMBERG INSTITUTE | 2014-09-04 | — | — | US | claimed |
| CN-103957908-A | Substituted aminothiazoles as inhibitors of cancer including hepatocellular carcinoma and as inhibitors of hepatitis virus replication | INST HEPATITIS & VIRUS RES | 2014-07-30 | — | — | CN | claimed |
| US-10087173-B2 | Substituted aminothiazoles as inhibitors of cancers, including hepatocellular carcinoma, and as inhibitors of hepatitis virus replication | BARUCH S. BLUMBERG INSTITUTE | 2018-10-02 | — | — | US | disclosed |
| US-20170066758-A1 | SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF CANCERS, INCLUDING HEPATOCELLULAR CARCINOMA, AND AS INHIBITORS OF HEPATITIS VIRUS REPLICATION | INSTITUTE FOR HEPATITIS AND VIRUS RESEARCH | 2017-03-09 | — | — | US | disclosed |
| US-20170066758-A1 | SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF CANCERS, INCLUDING HEPATOCELLULAR CARCINOMA, AND AS INHIBITORS OF HEPATITIS VIRUS REPLICATION | INSTITUTE FOR HEPATITIS AND VIRUS RESEARCH | 2017-03-09 | — | — | US | disclosed |
| US-20170066758-A1 | SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF CANCERS, INCLUDING HEPATOCELLULAR CARCINOMA, AND AS INHIBITORS OF HEPATITIS VIRUS REPLICATION | INSTITUTE FOR HEPATITIS AND VIRUS RESEARCH | 2017-03-09 | — | — | US | disclosed |
| CN-105585565-A | 2-phenylamino-4-thiazolyl pyridine derivatives, preparing method thereof, pharmaceutical compositions of the derivatives and uses of the derivatives | INST MATERIA MEDICA CAMS | 2016-05-18 | — | — | CN | disclosed |
| CN-105585565-A | 2-phenylamino-4-thiazolyl pyridine derivatives, preparing method thereof, pharmaceutical compositions of the derivatives and uses of the derivatives | INST MATERIA MEDICA CAMS | 2016-05-18 | — | — | CN | disclosed |
| CN-105585565-A | 2-phenylamino-4-thiazolyl pyridine derivatives, preparing method thereof, pharmaceutical compositions of the derivatives and uses of the derivatives | INST MATERIA MEDICA CAMS | 2016-05-18 | — | — | CN | disclosed |
| US-9079859-B2 | Synthetic lethal targeting of glucose transport | AUCKLAND UNISERVICES LIMITED (NZ) | 2015-07-14 | — | — | US | disclosed |
| US-20140249154-A1 | SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF CANCERS, INCLUDING HEPATOCELLULAR CARCINOMA, AND AS INHIBITORS OF HEPATITIS VIRUS REPLICATION | BARUCH S. BLUMBERG INSTITUTE | 2014-09-04 | — | — | US | disclosed |
| US-20140249154-A1 | SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF CANCERS, INCLUDING HEPATOCELLULAR CARCINOMA, AND AS INHIBITORS OF HEPATITIS VIRUS REPLICATION | BARUCH S. BLUMBERG INSTITUTE | 2014-09-04 | — | — | US | disclosed |
| US-20140249154-A1 | SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF CANCERS, INCLUDING HEPATOCELLULAR CARCINOMA, AND AS INHIBITORS OF HEPATITIS VIRUS REPLICATION | BARUCH S. BLUMBERG INSTITUTE | 2014-09-04 | — | — | US | disclosed |
| CN-103957908-A | Substituted aminothiazoles as inhibitors of cancer including hepatocellular carcinoma and as inhibitors of hepatitis virus replication | INST HEPATITIS & VIRUS RES | 2014-07-30 | — | — | CN | disclosed |
| US-20140128397-A1 | SYNTHETIC LETHAL TARGETING OF GLUCOSE TRANSPORT | RUGA CORPORATION | 2014-05-08 | — | — | US | disclosed |
| US-20110105436-A1 | HETEROARYL COMPOUNDS, COMPOSITIONS, AND METHODS OF USE IN CANCER TREATMENT | AUCKLAND UNISERVICES LIMITED (NZ) | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105436-A1 | HETEROARYL COMPOUNDS, COMPOSITIONS, AND METHODS OF USE IN CANCER TREATMENT | VHL, TP53, BECN1 | SMN1; SMN2 2531/4885MAPT 2506/4885NFKB1 2299/4885 |
| US-10087173-B2 | Substituted aminothiazoles as inhibitors of cancers, including hepatocellular carcinoma, and as inhibitors of hepatitis virus replication | HDGF, HCCS, BCAT1 | SMN1; SMN2 4776/4885MAPT 1418/4885NFKB1 927/4885 |
| US-20140249154-A1 | SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF CANCERS, INCLUDING HEPATOCELLULAR CARCINOMA, AND AS INHIBITORS OF HEPATITIS VIRUS REPLICATION | HCCS, BCAT1, AADAT | SMN1; SMN2 4745/4885MAPT 1916/4885NFKB1 838/4885 |
| US-20170066758-A1 | SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF CANCERS, INCLUDING HEPATOCELLULAR CARCINOMA, AND AS INHIBITORS OF HEPATITIS VIRUS REPLICATION | HDGF, HCCS, BCAT1 | SMN1; SMN2 4776/4885MAPT 1418/4885NFKB1 927/4885 |
| US-20140128397-A1 | SYNTHETIC LETHAL TARGETING OF GLUCOSE TRANSPORT | SLC2A1, SLC2A3, SLC2A2 | SMN1; SMN2 3423/4885MAPT 4397/4885NFKB1 1253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.