Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.41 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 8/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | PDE2A | O00408 | 4/20 | 0.40 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.39 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22438754 | 1.00 | FASN (0.43) | FASNMAP4K4MINK1TNIKTRPV1 | |
| SCHEMBL22438817 | 0.92 | EGLN1 (0.41) | FASNMAP4K4MINK1TNIKTRPV1 | |
| SCHEMBL23908259 | 0.90 | IDO1 (0.45) | FASNMAP4K4MINK1TNIKEGLN1 | |
| SCHEMBL22438887 | 0.89 | CYP2C9 (0.53) | FASNMAP4K4MINK1TNIKEGLN1 | |
| SCHEMBL22438916 | 0.88 | ROCK2 (0.47) | FASNMAP4K4MINK1TNIKEGLN1 | |
| SCHEMBL22438713 | 0.88 | EGLN1 (0.43) | FASNMAP4K4MINK1TNIKTRPV1 | |
| SCHEMBL22438582 | 0.88 | CXCR3 (0.43) | FASNMAP4K4MINK1TNIKTRPV1 | |
| SCHEMBL22685245 | 0.86 | MAP4K4 (0.41) | FASNMAP4K4MINK1TNIKTRPV1 | |
| SCHEMBL22438830 | 0.82 | IDO1 (0.59) | CYP2C9IDO1PDE2A | |
| SCHEMBL22685073 | 0.80 | IDO1 (0.41) | MAP4K4MINK1TNIKTRPV1EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11498904-B2 | Substituted biaryl compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors | MERCK SHARP & DOHME LLC (US) | 2022-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11498904-B2 | Substituted biaryl compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors | IDO1, IDO2, INMT | FASN 1115/4885MAP4K4 3403/4885MINK1 1312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.