Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CDC25B | P30305 | 2/20 | 0.40 |
| ▸ | CDC25A | P30304 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PTPRC | P08575 | 1/20 | 0.38 |
| ▸ | PTPRF | P10586 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30109325 | 1.00 | POLB (0.48) | POLBMAPK1HTTALOX15SMN1; SMN2 | |
| SCHEMBL30109123 | 0.90 | CTSS (0.41) | POLBNPC1ALDH1A1MAPTMEN1 | |
| SCHEMBL14908706 | 0.89 | CTSK (0.47) | ALDH1A1MAPTMEN1KMT2AATM | |
| SCHEMBL3760185 | 0.89 | CTSK (0.47) | ALDH1A1MAPTMEN1KMT2AATM | |
| SCHEMBL3374003 | 0.89 | CTSK (0.47) | ALDH1A1MAPTMEN1KMT2AATM | |
| SCHEMBL34471389 | 0.87 | ALDH1A1 (0.46) | POLBSMN1; SMN2NPC1ALDH1A1MAPT | |
| SCHEMBL12805657 | 0.83 | MAPT (0.44) | MAPK1HTTGAANPC1ALDH1A1 | |
| SCHEMBL12801920 | 0.82 | ALDH1A1 (0.35) | POLBNPC1ALDH1A1MAPTMEN1 | |
| SCHEMBL23017648 | 0.82 | KMT2A (0.43) | POLBHTTHSD17B10NPC1ALDH1A1 | |
| SCHEMBL14931121 | 0.81 | CTSS (0.41) | ALDH1A1MEN1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240360103-A1 | COMPLEMENT INHIBITION | SIXTH STREET LENDING PARTNERS | 2024-10-31 | — | — | US | disclosed |
| WO-2023278698-A1 | COMPLEMENT INHIBITION | APELLIS PHARMACEUTICALS, INC. (US) | 2023-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240360103-A1 | COMPLEMENT INHIBITION | C5, C9, C1QBP | POLB 2926/4885MAPK1 2787/4885HTT 185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.