Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 11/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 11/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 10/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 10/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 10/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 9/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 8/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 5/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | GABRE | P78334 | 1/20 | 0.38 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.38 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.38 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19555968 | 1.00 | GABRG2 (0.38) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL30489405 | 0.79 | OPRM1 (0.39) | USP30 | |
| SCHEMBL31704863 | 0.73 | MAPT (0.51) | GPR119 | |
| SCHEMBL11363885 | 0.73 | MAPT (0.51) | GPR119 | |
| SCHEMBL13105640 | 0.72 | GABRG2 (0.46) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL29563011 | 0.72 | GABRG2 (0.46) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL3700486 | 0.72 | GABRG2 (0.46) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL163615 | 0.72 | GABRG2 (0.46) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL5226281 | 0.72 | CFTR (0.49) | — | |
| SCHEMBL724883 | 0.71 | ALDH1A1 (0.50) | GABRG2GABRB3GABRA5GABRA1GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3710428-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2026-03-25 | — | — | EP | disclosed |
| CN-112204009-B | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2024-05-07 | — | — | CN | disclosed |
| CN-109641854-B | Modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2023-02-03 | — | — | CN | disclosed |