Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 9/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 4/20 | 0.37 |
| ▸ | CDK1 | P06493 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | MC3R | P41968 | 1/20 | 0.37 |
| ▸ | TP53BP1 | Q12888 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15289493 | 0.88 | CDK1 (0.50) | OPRM1USP30GSK3BCDK1CDK2 | |
| SCHEMBL944386 | 0.86 | USP30 (0.43) | OPRM1USP30CDK1CDK2TP53BP1 | |
| SCHEMBL30489430 | 0.80 | USP30 (0.47) | USP30GSK3BCDK2TSHR | |
| SCHEMBL30112012 | 0.79 | GABRG2 (0.38) | USP30 | |
| SCHEMBL19555968 | 0.79 | GABRG2 (0.38) | USP30 | |
| SCHEMBL30489402 | 0.76 | OPRM1 (0.39) | OPRM1ADORA3TSHRMC4RADRA1A | |
| SCHEMBL15511394 | 0.76 | HRH4 (0.54) | TP53BP1 | |
| SCHEMBL27691156 | 0.76 | HRH4 (0.50) | — | |
| SCHEMBL25797162 | 0.76 | USP30 (0.41) | USP30TP53BP1 | |
| SCHEMBL2563048 | 0.75 | USP30 (0.39) | OPRM1USP30GSK3BTP53BP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452456-B1 | BICYCLIC MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2023-07-05 | — | — | EP | disclosed |