Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | PLK1 | P53350 | 2/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.40 |
| ▸ | WEE1 | P30291 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27775430 | 0.84 | XDH (0.50) | MAPK8CDK2PLK1CHEK1PAK4 | |
| SCHEMBL28142469 | 0.83 | SYK (0.39) | CDK2ADRA2BWEE1STK10GSK3B | |
| SCHEMBL300845 | 0.82 | THRB (0.49) | MAPK1LMNATP53TSHRTHRB | |
| SCHEMBL300795 | 0.79 | KDM4E (0.59) | CSNK2A2MAPK1CSNK2BCSNK2A1LMNA | |
| SCHEMBL4239392 | 0.78 | SLC2A1 (0.34) | MAPK8CDK2PLK1CHEK1PAK4 | |
| SCHEMBL300887 | 0.75 | LMNA (0.51) | MAPK1SCN9ALMNATP53TSHR | |
| SCHEMBL1748994 | 0.75 | HSD17B10 (0.48) | MAPK8CDK2PLK1CHEK1PAK4 | |
| SCHEMBL15206286 | 0.69 | GSK3B (0.48) | PLK1MAPK1WEE1LMNATSHR | |
| SCHEMBL301233 | 0.68 | KDM4E (0.61) | CSNK2A2MAPK1CSNK2BCSNK2A1LMNA | |
| SCHEMBL28142358 | 0.68 | CHKA (0.39) | ADRA2BLMNATP53TSHRABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078018-B1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | SIGNAL PHARM LLC (US) | 2012-03-14 | — | — | EP | claimed |
| CN-107976546-B | Inhibition of phosphorylation of TOR kinase inhibitory Activity markers PRAS40, GSK 3-beta, or P70S6K1 | 西格诺药品有限公司 | 2020-10-27 | — | — | CN | disclosed |
| CN-110721186-A | Treatment of prostate cancer with TOR kinase inhibitors | 西格诺药品有限公司 | 2020-01-24 | — | — | CN | disclosed |
| CN-107157990-B | Treatment of cancer with TOR kinase inhibitors | 西格诺药品有限公司 | 2020-01-07 | — | — | CN | disclosed |
| CN-109846884-A | With TOR kinase inhibitor for treating cancer | 西格诺药品有限公司 | 2019-06-07 | — | — | CN | disclosed |
| CN-108992446-A | With TOR kinase inhibitor for treating cancer | 西格诺药品有限公司 | 2018-12-14 | — | — | CN | disclosed |
| CN-104271159-B | The method that non-small cell lung cancer is treated using the therapeutic alliance of TOR kinase inhibitors | 西格诺药品有限公司 | 2017-11-28 | — | — | CN | disclosed |
| CN-107157990-A | Utilize TOR kinase inhibitor for treating cancers | 西格诺药品有限公司 | 2017-09-15 | — | — | CN | disclosed |
| CN-107137402-A | With TOR kinase inhibitor for treating cancers | 西格诺药品有限公司 | 2017-09-08 | — | — | CN | disclosed |
| CN-104302295-B | Treatment of cancer with TOR kinase inhibitors | 西格诺药品有限公司 | 2017-06-20 | — | — | CN | disclosed |
| CN-103998036-B | Treatment of cancer with TOR kinase inhibitors | 西格诺药品有限公司 | 2017-05-31 | — | — | CN | disclosed |
| CN-105050601-A | Treatment of prostate cancer with TOR kinase inhibitors | SIGNAL PHARM LLC | 2015-11-11 | — | — | CN | disclosed |
| CN-104519885-A | Treatment of cancer with TOR kinase inhibitors | SIGNAL PHARM LLC | 2015-04-15 | — | — | CN | disclosed |
| CN-104302295-A | Treatment of cancer with tor kinase inhibitors | SIGNAL PHARM LLC | 2015-01-21 | — | — | CN | disclosed |
| CN-104271138-A | Treatment of cancer with tor kinase inhibitors | SIGNAL PHARM LLC | 2015-01-07 | — | — | CN | disclosed |
| CN-104271139-A | Treatment of cancer with tor kinase inhibitors | SIGNAL PHARM LLC | 2015-01-07 | — | — | CN | disclosed |
| CN-104271159-A | Methods for treating non- small cell lung cancer using tor kinase inhibitor combination therapy | SIGNAL PHARM LLC | 2015-01-07 | — | — | CN | disclosed |
| EP-2078018-A1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | Signal Pharmaceuticals LLC (US) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008051494-A1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-05-02 | — | — | WO | disclosed |