Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | PLK1 | P53350 | 3/20 | 0.32 |
| ▸ | FLT3 | P36888 | 2/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | CHKA | P35790 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 2/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | PAK4 | O96013 | 1/20 | 0.32 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.32 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL301187 | 0.78 | MAPK8 (0.41) | SLC2A1MAPK8MAPK9PLK1CDK2 | |
| SCHEMBL27775430 | 0.73 | XDH (0.50) | XDHMAPK8PLK1CHKACDK2 | |
| SCHEMBL300795 | 0.65 | KDM4E (0.59) | CSNK2A2MAPK1CSNK2BCSNK2A1 | |
| SCHEMBL28142469 | 0.64 | SYK (0.39) | KDRCDK2EGFRFGFR1PDGFRA | |
| SCHEMBL300845 | 0.63 | THRB (0.49) | CHKAMAPK1 | |
| SCHEMBL27776131 | 0.62 | CSNK2A1 (0.60) | CSNK2A2MAPK1CSNK2BCSNK2A1 | |
| SCHEMBL1748994 | 0.62 | HSD17B10 (0.48) | MAPK8MAPK9PLK1FLT3KDR | |
| SCHEMBL15206286 | 0.58 | GSK3B (0.48) | PLK1KDRMAPK1EGFRABL1 | |
| SCHEMBL27796479 | 0.57 | XDH (0.53) | XDHCHKAMAPK1CSNK2A1SRC | |
| SCHEMBL27784932 | 0.57 | SYK (0.42) | MAPK8MAPK9PLK1FLT3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078018-A1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | Signal Pharmaceuticals LLC (US) | 2009-07-15 | — | — | EP | claimed |
| WO-2008051494-A1 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-05-02 | — | — | WO | claimed |