Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 3/20 | 0.57 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.57 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.45 |
| ▸ | ATR | Q13535 | 2/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30129746 | 0.76 | HSD17B1 (0.47) | HSD17B1HSD17B2MAP4K4FYN | |
| SCHEMBL3024116 | 0.74 | BCHE (0.67) | HSD17B1HSD17B2ATRMAPK10 | |
| SCHEMBL1180306 | 0.74 | HSD17B1 (1.00) | HSD17B1HSD17B2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL30129734 | 0.73 | HSD17B1 (0.45) | HSD17B1HSD17B2PIK3CAPIK3CDMETAP2 | |
| SCHEMBL2317303 | 0.71 | HSD17B1 (0.51) | HSD17B1HSD17B2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL10200397 | 0.70 | PIK3CA (0.43) | HSD17B1HSD17B2PIK3CAPIK3CDMETAP2 | |
| SCHEMBL30186373 | 0.69 | HSD17B1 (0.79) | HSD17B1HSD17B2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL2319574 | 0.69 | HSD17B1 (0.51) | HSD17B1HSD17B2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL2321967 | 0.69 | HSD17B1 (0.56) | HSD17B1HSD17B2PIK3CGPIK3CAPIK3CB | |
| SCHEMBL30862097 | 0.68 | HSD17B1 (0.66) | HSD17B1HSD17B2METAP2CHEK1MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230069804-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPLICING | SKYHAWK THERAPEUTICS, INC. | 2023-03-02 | — | — | US | disclosed |
| US-20230027684-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPLICING | SKYHAWK THERAPEUTICS, INC. | 2023-01-26 | — | — | US | disclosed |
| US-20230008867-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPLICING | SKYHAWK THERAPEUTICS, INC. | 2023-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230008867-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPLICING | RBM17, SF3B1, SNRPA1 | HSD17B1 2388/4885HSD17B2 2816/4885PIK3CG 2223/4885 |
| US-20230027684-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPLICING | RBM17, SF3B1, SF3B5 | HSD17B1 2342/4885HSD17B2 2758/4885PIK3CG 2230/4885 |
| US-20230069804-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPLICING | RBM17, SF3B1, SF3B5 | HSD17B1 2342/4885HSD17B2 2758/4885PIK3CG 2230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.