Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.37 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.37 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 10/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | NAAA | Q02083 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28783627 | 0.81 | GNAI3 (0.55) | EPHX1GNAI3GNAO1GNAI1ACHE | |
| SCHEMBL29751587 | 0.78 | LMNA (0.48) | ALDH1A1SMN1; SMN2ATM | |
| Hydrochloric Acid SCHEMBL30406528 | 0.77 | LMNA (0.47) | GNAI3GNAO1GNAI1ALDH1A1SMN1; SMN2 | |
| SCHEMBL30802452 | 0.75 | GAA (0.44) | EPHX1GNAI3GNAO1GNAI1ACHE | |
| SCHEMBL6381523 | 0.73 | SMN1; SMN2 (0.40) | EPHX1ACHEALDH1A1NPC1MAPT | |
| SCHEMBL22495693 | 0.72 | ACHE (0.46) | EPHX1ACHEALDH1A1 | |
| SCHEMBL1383077 | 0.72 | SMN1; SMN2 (0.50) | EPHX1ACHEALDH1A1NPC1MAPT | |
| SCHEMBL7841197 | 0.72 | SMN1; SMN2 (0.47) | EPHX1ACHEALDH1A1NPC1MAPT | |
| SCHEMBL20570038 | 0.72 | LMNA (0.48) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL21409258 | 0.71 | LMNA (0.54) | ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4157850-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | Uppthera, Inc. (KR) | 2023-04-05 | — | — | EP | disclosed |
| WO-2023018236-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |
| WO-2023017446-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-02-16 | — | — | WO | disclosed |