Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13207454 | 0.79 | TDP1 (0.40) | EPHX2TDP1EPHX1SMN1; SMN2LMNA | |
| SCHEMBL3008613 | 0.76 | HSD11B1 (0.36) | EPHX2TDP1EPHX1SMN1; SMN2LMNA | |
| SCHEMBL15022007 | 0.76 | EPHX2 (0.49) | EPHX2TDP1SMN1; SMN2LMNAHSD11B1 | |
| SCHEMBL24927361 | 0.70 | EPHX1 (0.43) | EPHX2TDP1EPHX1SMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL28651729 | 0.69 | EPHX2 (0.38) | EPHX2TDP1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL6686034 | 0.66 | L3MBTL1 (0.45) | EPHX2TDP1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL1778693 | 0.65 | SMN1; SMN2 (0.61) | EPHX2TDP1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL9974906 | 0.65 | SMN1; SMN2 (0.45) | EPHX2TDP1SMN1; SMN2LMNAHSD11B1 | |
| SCHEMBL12344538 | 0.63 | LMNA (0.48) | EPHX2TDP1SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL14573044 | 0.63 | EPHX2 (0.53) | EPHX2TDP1SMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8835426-B2 | Cyclic urea and carbamate inhibitors of 11β-hydroxysteroid dehydrogenase 1 | VITAE PHARMACEUTICALS, INC. (US) | 2014-09-16 | — | — | US | disclosed |
| US-20100197675-A1 | CYCLIC UREA AND CARBAMATE INHIBITORS OF 11 BETA-HYDROXYSTEROID DEHYDROGENASE 1 | VITAE PHARMACEUTICALS, INC. | 2010-08-05 | — | — | US | disclosed |
| EP-2125750-A2 | CYCLIC UREA AND CARBAMATE INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | Vitae Pharmaceuticals, Inc. (US) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008106128-A2 | CYCLIC UREA AND CARBAMATE INHIBITORS OF 11β -HYDROXYSTEROID DEHYDROGENASE 1 | VITAE PHARMACEUTICALS, INC. (US) | 2008-09-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197675-A1 | CYCLIC UREA AND CARBAMATE INHIBITORS OF 11 BETA-HYDROXYSTEROID DEHYDROGENASE 1 | HSD11B1, HSD3B1, HSD11B2 | EPHX2 1527/4885TDP1 863/4885EPHX1 999/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.