Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.37 |
| ▸ | EIF4E | P06730 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30145295 | 0.91 | ALDH1A3 (0.43) | ALDH1A3HSP90AA1HSP90AB1HSD17B10MAPT | |
| SCHEMBL20596557 | 0.87 | MAPT (0.43) | ALDH1A3HSD17B10MAPTCDC7DBF4 | |
| SCHEMBL20596534 | 0.83 | LMNA (0.39) | ALDH1A3HSP90AA1HSP90AB1MAPTCSNK1D | |
| SCHEMBL30145335 | 0.75 | MARS2 (0.43) | HSP90AA1HSP90AB1PLA2G2AMAPTCDC7 | |
| SCHEMBL20595826 | 0.73 | MARS2 (0.52) | ALDH1A3HSP90AA1HSP90AB1PPARG | |
| SCHEMBL30145166 | 0.73 | MARS2 (0.52) | ALDH1A3HSP90AA1HSP90AB1PPARG | |
| SCHEMBL20595977 | 0.72 | MARS2 (0.54) | ALDH1A3HSP90AA1HSP90AB1PPARG | |
| SCHEMBL30145251 | 0.72 | MARS2 (0.54) | ALDH1A3HSP90AA1HSP90AB1PPARG | |
| SCHEMBL14736753 | 0.72 | SMN1; SMN2 (0.57) | HSD17B10MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL20596077 | 0.68 | HSP90AA1 (0.39) | HSP90AA1HSP90AB1HSD17B10MAPTCDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11584744-B2 | Inhibitors of type 1 methionyl-tRNA synthetase and methods of using them | UNIVERSITY OF WASHINGTON (US) | 2023-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11584744-B2 | Inhibitors of type 1 methionyl-tRNA synthetase and methods of using them | AARS1, EMG1, GARS1 | ALDH1A3 1695/4885HSP90AA1 887/4885HSP90AB1 958/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.