SCHEMBL30161533

SCHEMBL30161533

O=S(=O)(Cl)c1cc(C(F)(F)F)ccc1C(F)(F)F

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPV4 Q9HBA0 1/20 0.47
CES2 O00748 2/20 0.47
ALDH1A1 P00352 2/20 0.44
L3MBTL1 Q9Y468 2/20 0.44
MEN1 O00255 1/20 0.44
TSHR P16473 1/20 0.44
KMT2A Q03164 1/20 0.44
ATM Q13315 1/20 0.44
MCL1 Q07820 4/20 0.39
FLT1 P17948 1/20 0.38
FLT4 P35916 1/20 0.38
KDR P35968 1/20 0.38
PDE2A O00408 2/20 0.38
TOP2A P11388 1/20 0.38
EPAS1 Q99814 1/20 0.38
CYP3A4 P08684 1/20 0.37
CYP2C9 P11712 1/20 0.37
SLC22A6 Q4U2R8 1/20 0.37
SLC22A8 Q8TCC7 1/20 0.37
SLC22A12 Q96S37 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL941069 1.00 TRPV4 (0.47) TRPV4CES2ALDH1A1L3MBTL1MEN1
SCHEMBL3611597 0.85 TRPV4 (0.60) TRPV4CES2ALDH1A1L3MBTL1MEN1
SCHEMBL29374110 0.85 TRPV4 (0.60) TRPV4CES2ALDH1A1L3MBTL1MEN1
SCHEMBL3410514 0.81 TRPV4 (0.47) TRPV4MCL1SLC22A12
SCHEMBL29913652 0.81 CA1 (0.55) CES2ALDH1A1L3MBTL1MEN1TSHR
SCHEMBL23841300 0.81 CES2 (0.47) CES2ALDH1A1L3MBTL1MEN1TSHR
SCHEMBL3190051 0.81 CES2 (0.52) CES2ALDH1A1L3MBTL1MEN1TSHR
SCHEMBL4617448 0.81 TRPV4 (0.47) TRPV4MEN1KMT2AMCL1SLC22A12
SCHEMBL18985068 0.81 CA1 (0.55) CES2ALDH1A1L3MBTL1MEN1TSHR
SCHEMBL30161606 0.81 MEN1 (0.44) TRPV4ALDH1A1L3MBTL1MEN1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3558298-B1 ANTIDIABETIC SPIROCHROMAN COMPOUNDS MERCK SHARP & DOHME LLC (US) 2026-03-11 EP disclosed
WO-2025075722-A1 PRODUCTION METHOD FOR SOLID CATALYST COMPONENT FOR POLYMERIZING OLEFINS, AND CATALYST FOR POLYMERIZAING OLEFINS FORMOSA PLASTICS CORPORATION, U.S.A. (US) 2025-04-10 WO disclosed
CN-119264303-A Pendant group functionalized fluorine-containing polymer, preparation method of fluorine-containing polymer, ion exchange membrane and application 佛山绿动氢能科技有限公司 2025-01-07 CN disclosed
CN-112015048-B Photoresist pattern trimming composition and pattern forming method 罗门哈斯电子材料有限责任公司 2025-01-03 CN disclosed
CN-118063450-A Arylsulfonamide compound, preparation method and pharmaceutical application thereof 中国医学科学院药物研究所 2024-05-24 CN disclosed
CN-115768750-A GCN2 modulator compounds 阿莱斯塔治疗公司 2023-03-07 CN disclosed
EP-4107146-A1 GCN2 MODULATOR COMPOUNDS Alesta Therapeutics BV (NL) 2022-12-28 EP disclosed