SCHEMBL4617448

SCHEMBL4617448

O=S(=O)(Cl)c1cc(F)ccc1C(F)(F)F

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPV4 Q9HBA0 1/20 0.47
MCL1 Q07820 2/20 0.38
PTGES2 Q9H7Z7 2/20 0.37
KIF11 P52732 4/20 0.37
SLC22A12 Q96S37 3/20 0.36
HSD11B1 P28845 1/20 0.36
IDO1 P14902 2/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
FFAR4 Q5NUL3 1/20 0.36
GSTO1 P78417 1/20 0.35
CA12 O43570 1/20 0.34
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
CA4 P22748 1/20 0.34
CA6 P23280 1/20 0.34
CA5A P35218 1/20 0.34
CA7 P43166 1/20 0.34
CA9 Q16790 1/20 0.34
CA14 Q9ULX7 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30395525 0.85 TRPV4 (0.60) TRPV4MCL1PTGES2HSD11B1IDO1
SCHEMBL695151 0.85 TRPV4 (0.60) TRPV4MCL1PTGES2HSD11B1IDO1
SCHEMBL4616832 0.83 HSD11B1 (0.45) TRPV4KIF11HSD11B1FFAR4
SCHEMBL30161533 0.81 TRPV4 (0.47) TRPV4MCL1SLC22A12HSD11B1MEN1
SCHEMBL3410514 0.81 TRPV4 (0.47) TRPV4MCL1SLC22A12FFAR4
SCHEMBL941069 0.81 TRPV4 (0.47) TRPV4MCL1SLC22A12HSD11B1MEN1
SCHEMBL3203638 0.81 PTGES2 (0.37) MCL1PTGES2KIF11SLC22A12IDO1
SCHEMBL31296460 0.81 CA12 (0.55) PTGES2KIF11IDO1MEN1KMT2A
SCHEMBL25450219 0.79 TRPV4 (0.46) TRPV4MCL1PTGES2KIF11SLC22A12
SCHEMBL29451830 0.79 TRPV4 (0.46) TRPV4SLC22A12HSD11B1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120005064-A Aryl ion polymer and preparation method and application thereof 佛山绿动氢能科技有限公司 2025-05-16 CN disclosed
CN-119264303-A Pendant group functionalized fluorine-containing polymer, preparation method of fluorine-containing polymer, ion exchange membrane and application 佛山绿动氢能科技有限公司 2025-01-07 CN disclosed
CN-119219809-A Fluorine-containing polymer, preparation method thereof and ion exchange membrane 佛山绿动氢能科技有限公司 2024-12-31 CN disclosed
EP-3404017-B1 FLUORINE ATOM-CONTAINING COMPOUND AND USE THEREOF NISSAN CHEMICAL IND LTD (JP) 2020-05-13 EP disclosed
US-10336686-B2 Fluorine atom-containing compound and use thereof NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2019-07-02 US disclosed
US-20190031600-A1 FLUORINE ATOM-CONTAINING COMPOUND AND USE THEREOF NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2019-01-31 US disclosed
EP-3404017-A1 FLUORINE ATOM-CONTAINING COMPOUND AND USE THEREOF Nissan Chemical Industries, Ltd. (JP) 2018-11-21 EP disclosed
EP-1879859-A2 DIARYLSULFONE SULFONAMIDES AND USE THEROF Wyeth a Corporation of the State of Delaware (US) 2008-01-23 EP disclosed
US-20060276464-A1 Diarylsulfone sulfonamides and use thereof WYETH (US) 2006-12-07 US disclosed
WO-2006124875-A2 DIARYLSULFONE SULFONAMIDES AND USE THEROF WYETH (US) 2006-11-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10336686-B2 Fluorine atom-containing compound and use thereof ARF1, ARF5, ARFGAP1 TRPV4 3714/4885MCL1 434/4885PTGES2 4879/4885
US-20190031600-A1 FLUORINE ATOM-CONTAINING COMPOUND AND USE THEREOF ARF1, ARF5, ARFGAP1 TRPV4 3714/4885MCL1 434/4885PTGES2 4879/4885
US-20060276464-A1 Diarylsulfone sulfonamides and use thereof SFRP1, SOS1, FZD7 TRPV4 1466/4885MCL1 1442/4885PTGES2 3451/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.