SCHEMBL941069

SCHEMBL941069

O=S(=O)(Cl)c1cc(C(F)(F)F)ccc1C(F)(F)F

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPV4 Q9HBA0 1/20 0.47
CES2 O00748 2/20 0.47
ALDH1A1 P00352 2/20 0.44
L3MBTL1 Q9Y468 2/20 0.44
MEN1 O00255 1/20 0.44
TSHR P16473 1/20 0.44
KMT2A Q03164 1/20 0.44
ATM Q13315 1/20 0.44
MCL1 Q07820 4/20 0.39
FLT1 P17948 1/20 0.38
FLT4 P35916 1/20 0.38
KDR P35968 1/20 0.38
PDE2A O00408 2/20 0.38
TOP2A P11388 1/20 0.38
EPAS1 Q99814 1/20 0.38
CYP3A4 P08684 1/20 0.37
CYP2C9 P11712 1/20 0.37
SLC22A6 Q4U2R8 1/20 0.37
SLC22A8 Q8TCC7 1/20 0.37
SLC22A12 Q96S37 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30161533 1.00 TRPV4 (0.47) TRPV4CES2ALDH1A1L3MBTL1MEN1
SCHEMBL3611597 0.85 TRPV4 (0.60) TRPV4CES2ALDH1A1L3MBTL1MEN1
SCHEMBL29374110 0.85 TRPV4 (0.60) TRPV4CES2ALDH1A1L3MBTL1MEN1
SCHEMBL3410514 0.81 TRPV4 (0.47) TRPV4MCL1SLC22A12
SCHEMBL29913652 0.81 CA1 (0.55) CES2ALDH1A1L3MBTL1MEN1TSHR
SCHEMBL23841300 0.81 CES2 (0.47) CES2ALDH1A1L3MBTL1MEN1TSHR
SCHEMBL3190051 0.81 CES2 (0.52) CES2ALDH1A1L3MBTL1MEN1TSHR
SCHEMBL4617448 0.81 TRPV4 (0.47) TRPV4MEN1KMT2AMCL1SLC22A12
SCHEMBL18985068 0.81 CA1 (0.55) CES2ALDH1A1L3MBTL1MEN1TSHR
SCHEMBL30161606 0.81 MEN1 (0.44) TRPV4ALDH1A1L3MBTL1MEN1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12630529-B2 GCN2 modulator compounds Alesta Therapeutics BV (NL) 2026-05-19 US disclosed
US-20250115687-A1 PRODUCTION METHOD FOR SOLID CATALYST COMPONENT FOR POLYMERIZING OLEFINS, AND CATALYST FOR POLYMERIZAING OLEFINS FORMOSA PLASTICS CORP USA (US) 2025-04-10 US disclosed
US-11754927-B2 Photoresist pattern trimming compositions and pattern formation methods ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2023-09-12 US disclosed
US-20230143059-A1 GCN2 MODULATOR COMPOUNDS Alesta Therapeutics BV (NL) 2023-05-11 US disclosed
US-20230143059-A1 GCN2 MODULATOR COMPOUNDS Alesta Therapeutics BV (NL) 2023-05-11 US disclosed
EP-4107146-A1 GCN2 MODULATOR COMPOUNDS Alesta Therapeutics BV (NL) 2022-12-28 EP disclosed
US-11236055-B2 Non-systemic TGR5 agonists Venenum Biodesign, LLC (US) 2022-02-01 US disclosed
US-10968232-B2 Antidiabetic spirochroman compounds MERCK SHARP & DOHME CORP. (US) 2021-04-06 US disclosed
US-20200379353-A1 PHOTORESIST PATTERN TRIMMING COMPOSITIONS AND PATTERN FORMATION METHODS U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS NOTES COLLATERAL AGENT 2020-12-03 US disclosed
US-20200308122-A1 NOVEL NON-SYSTEMIC TGR5 AGONISTS Venenum Biodesign, LLC (US) 2020-10-01 US disclosed
WO-2002008201-A2 BETA-AMINO ACID DERIVATIVES-INHIBITORS OF LEUKOCYTE ADHESION MEDIATED BY VLA-4 ELAN PHARMACEUTICALS, INC. (US) 2002-01-31 WO disclosed
WO-2002006223-A1 1,3-DISUBSTITUTED AND 1,3,3-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS ABBOTT LABORATORIES (US) 2002-01-24 WO disclosed
EP-1147091-A2 FUSED RING HETEROARYL AND HETEROCYCLIC COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 Elan Pharmaceuticals, Inc. (US) 2001-10-24 EP disclosed
EP-1144388-A1 ACYL DERIVATIVES WHICH TREAT VLA-4 RELATED DISORDERS Elan Pharmaceuticals, Inc. (US) 2001-10-17 EP disclosed
WO-2000043371-A2 FUSED RING HETEROARYL AND HETEROCYCLIC COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 ELAN PHARMACEUTICALS, INC. (US) 2000-07-27 WO disclosed
WO-2000043372-A1 ACYL DERIVATIVES WHICH TREAT VLA-4 RELATED DISORDERS ELAN PHARMACEUTICALS, INC. (US) 2000-07-27 WO disclosed
EP-1000051-A1 CARBAMYLOXY COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 Elan Pharmaceuticals, Inc. (US) 2000-05-17 EP disclosed
EP-0994895-A1 DIPEPTIDE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 Elan Pharmaceuticals, Inc. (US) 2000-04-26 EP disclosed
WO-1999006435-A1 DIPEPTIDE COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 ELAN PHARMACEUTICALS, INC. (US) 1999-02-11 WO disclosed
WO-1999006390-A1 CARBAMYLOXY COMPOUNDS WHICH INHIBIT LEUKOCYTE ADHESION MEDIATED BY VLA-4 ELAN PHARMACEUTICALS, INC. (US) 1999-02-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200308122-A1 NOVEL NON-SYSTEMIC TGR5 AGONISTS GPR119, SSTR5, FFAR3 TRPV4 330/4885CES2 1340/4885ALDH1A1 2874/4885
US-12630529-B2 GCN2 modulator compounds NR3C1, GCN1, EIF2AK4 TRPV4 2630/4885CES2 2191/4885ALDH1A1 4260/4885
US-10968232-B2 Antidiabetic spirochroman compounds GPR119, GPR52, GPR55 TRPV4 204/4885CES2 2478/4885ALDH1A1 1981/4885
US-20230143059-A1 GCN2 MODULATOR COMPOUNDS EIF2AK4, GPR119, GCN1 TRPV4 2116/4885CES2 2859/4885ALDH1A1 4030/4885
US-11236055-B2 Non-systemic TGR5 agonists SSTR5, GPR119, FFAR3 TRPV4 338/4885CES2 1390/4885ALDH1A1 2815/4885
US-11754927-B2 Photoresist pattern trimming compositions and pattern formation methods AHR, ALKBH1, CNOT1 TRPV4 3825/4885CES2 1835/4885ALDH1A1 298/4885
US-20200379353-A1 PHOTORESIST PATTERN TRIMMING COMPOSITIONS AND PATTERN FORMATION METHODS AHR, ALKBH1, CNOT1 TRPV4 3825/4885CES2 1835/4885ALDH1A1 298/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.