Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 11/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 9/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.37 |
| ▸ | HTR1D | P28221 | 2/20 | 0.37 |
| ▸ | HTR1B | P28222 | 2/20 | 0.37 |
| ▸ | HTR1F | P30939 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29239375 | 1.00 | ADORA2B (0.40) | ADORA2BADORA2AADORA1ABL1GSK3B | |
| SCHEMBL29239372 | 1.00 | ADORA2B (0.40) | ADORA2BADORA2AADORA1ABL1GSK3B | |
| SCHEMBL29239398 | 0.78 | ADORA2B (0.46) | ADORA2BADORA2AADORA1ABL1GSK3B | |
| SCHEMBL24992530 | 0.78 | ADORA2B (0.46) | ADORA2BADORA2AADORA1ABL1GSK3B | |
| SCHEMBL30173072 | 0.78 | ADORA2B (0.46) | ADORA2BADORA2AADORA1ABL1GSK3B | |
| SCHEMBL29814571 | 0.76 | ADORA2B (0.48) | ADORA2BADORA2AADORA1GSK3BGSK3A | |
| SCHEMBL23089063 | 0.76 | ADORA2B (0.48) | ADORA2BADORA2AADORA1GSK3BGSK3A | |
| SCHEMBL28876487 | 0.76 | ADORA2B (0.48) | ADORA2BADORA2AADORA1GSK3BGSK3A | |
| SCHEMBL23089798 | 0.74 | ADORA2B (0.53) | ADORA2BADORA2AADORA1GSK3BGSK3A | |
| SCHEMBL24992531 | 0.73 | HTR1A (0.41) | ABL1HPGDHTR1AHTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4380565-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2024-06-12 | — | — | EP | disclosed |
| CN-117915912-A | HPK1 antagonists and uses thereof | 林伯士萨顿公司 | 2024-04-19 | — | — | CN | disclosed |
| WO-2023015199-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2023-02-09 | — | — | WO | disclosed |