Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.40 |
| ▸ | ATF1 | P18846 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | FOS | P01100 | 2/20 | 0.36 |
| ▸ | JUN | P05412 | 2/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.36 |
| ▸ | RELA | Q04206 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30202755 | 0.86 | NFKB1 (0.50) | ALDH1A1KDM4ENFKB1ATF1MAPT | |
| SCHEMBL24952216 | 0.86 | NFKB1 (0.50) | ALDH1A1KDM4ENFKB1ATF1MAPT | |
| SCHEMBL24951472 | 0.75 | NFKB1 (0.46) | ALDH1A1KDM4ENFKB1ATF1MAPT | |
| SCHEMBL24951630 | 0.73 | ALDH1A1 (0.50) | ALDH1A1KDM4ENFKB1ATF1MAPT | |
| SCHEMBL30202869 | 0.73 | ALDH1A1 (0.50) | ALDH1A1KDM4ENFKB1ATF1MAPT | |
| SCHEMBL24951126 | 0.71 | NFKB1 (0.50) | ALDH1A1KDM4ENFKB1ATF1MAPT | |
| SCHEMBL30202837 | 0.71 | NFKB1 (0.50) | ALDH1A1KDM4ENFKB1ATF1MAPT | |
| SCHEMBL11363820 | 0.70 | ALDH1A1 (0.54) | ALDH1A1KDM4ENFKB1MAPTRAB9A | |
| SCHEMBL29029338 | 0.70 | SMN1; SMN2 (0.48) | ALDH1A1KDM4EMAPTPOLBRAB9A | |
| SCHEMBL24577041 | 0.69 | HSD17B10 (0.39) | ALDH1A1KDM4EMAPTPOLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4376845-A1 | PYRAZOLOPYRIMIDINES AND THEIR USES AS PDGFR INHIBITORS | Actelion Pharmaceuticals Ltd (CH) | 2024-06-05 | — | — | EP | disclosed |
| WO-2023007009-A1 | PYRAZOLOPYRIMIDINES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-02-02 | — | — | WO | disclosed |