Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 8/20 | 0.50 |
| ▸ | ATF1 | P18846 | 5/20 | 0.50 |
| ▸ | JUN | P05412 | 3/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.44 |
| ▸ | RELA | Q04206 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | XPO1 | O14980 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24952216 | 1.00 | NFKB1 (0.50) | NFKB1ATF1JUNNFKB2RELA | |
| SCHEMBL30202695 | 0.86 | ALDH1A1 (0.40) | NFKB1ATF1JUNNFKB2RELA | |
| SCHEMBL30202869 | 0.86 | ALDH1A1 (0.50) | NFKB1ATF1JUNNFKB2RELA | |
| SCHEMBL24951630 | 0.86 | ALDH1A1 (0.50) | NFKB1ATF1JUNNFKB2RELA | |
| SCHEMBL24951472 | 0.86 | NFKB1 (0.46) | NFKB1ATF1JUNNFKB2RELA | |
| SCHEMBL24951126 | 0.84 | NFKB1 (0.50) | NFKB1ATF1JUNNFKB2RELA | |
| SCHEMBL30202837 | 0.84 | NFKB1 (0.50) | NFKB1ATF1JUNNFKB2RELA | |
| SCHEMBL476310 | 0.76 | ALDH1A1 (0.59) | NFKB1ATF1ALDH1A1KDM4ERAB9A | |
| SCHEMBL29922173 | 0.76 | ALDH1A1 (0.59) | NFKB1ATF1ALDH1A1KDM4ERAB9A | |
| SCHEMBL30202952 | 0.76 | JUN (0.46) | NFKB1JUNNFKB2RELAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4376845-A1 | PYRAZOLOPYRIMIDINES AND THEIR USES AS PDGFR INHIBITORS | Actelion Pharmaceuticals Ltd (CH) | 2024-06-05 | — | — | EP | disclosed |
| WO-2023007009-A1 | PYRAZOLOPYRIMIDINES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-02-02 | — | — | WO | disclosed |