Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.45 |
| ▸ | RAB9A | P51151 | 8/20 | 0.45 |
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | NISCH | Q9Y2I1 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.40 |
| ▸ | RELA | Q04206 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7517539 | 0.86 | NISCH (0.41) | NPC1RAB9AMAPTSMN1; SMN2NISCH | |
| SCHEMBL28002482 | 0.83 | LMNA (0.41) | NPC1RAB9AMAPTSMN1; SMN2TP53 | |
| SCHEMBL28002189 | 0.83 | MAPT (0.41) | NPC1RAB9AMAPTSMN1; SMN2NISCH | |
| SCHEMBL27921193 | 0.80 | NISCH (0.36) | NPC1RAB9AMAPTSMN1; SMN2NISCH | |
| SCHEMBL4847120 | 0.76 | NPC1 (0.56) | NPC1RAB9AMAPTSMN1; SMN2HPGD | |
| SCHEMBL27379957 | 0.76 | CYP19A1 (0.42) | RAB9AMAPTSMN1; SMN2NISCHHPGD | |
| SCHEMBL1398128 | 0.74 | NOS3 (0.39) | NPC1RAB9AMAPTSMN1; SMN2HPGD | |
| SCHEMBL9855245 | 0.72 | NISCH (0.47) | RAB9AMAPTSMN1; SMN2NISCHHPGD | |
| SCHEMBL28002164 | 0.71 | NPC1 (0.47) | NPC1RAB9AMAPTSMN1; SMN2NISCH | |
| SCHEMBL14180628 | 0.70 | RAB9A (0.39) | NPC1RAB9AMAPTSMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115710251-A | Myeloid differentiation factor 88 inhibitor and preparation method and application thereof | 杭州医学院 | 2023-02-24 | — | — | CN | disclosed |