Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SCN2B | O60939 | 2/20 | 0.41 |
| ▸ | SCN1B | Q07699 | 2/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | SCN1A | P35498 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.40 |
| ▸ | MERTK | Q12866 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21786023 | 1.00 | NOTUM (0.57) | NOTUMALDH1A1L3MBTL1KDM4EHPGD | |
| SCHEMBL679402 | 0.85 | KDM4E (0.57) | NOTUMALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL679241 | 0.84 | LMNA (0.57) | NOTUMALDH1A1L3MBTL1KDM4EHPGD | |
| SCHEMBL21785514 | 0.84 | ALDH1A1 (0.49) | NOTUMALDH1A1L3MBTL1KDM4EHPGD | |
| SCHEMBL30208868 | 0.82 | ALDH1A1 (0.52) | NOTUMALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL21786022 | 0.82 | ALDH1A1 (0.52) | NOTUMALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL24878824 | 0.76 | L3MBTL1 (0.45) | NOTUMALDH1A1L3MBTL1SCN2BSCN1B | |
| SCHEMBL1259527 | 0.73 | NOTUM (0.66) | NOTUMALDH1A1L3MBTL1KDM4ELMNA | |
| Fluorofenidone SCHEMBL1047536 | 0.73 | ALDH1A1 (0.64) | NOTUMALDH1A1L3MBTL1KDM4EHPGD | |
| Fluorofenidone SCHEMBL29420525 | 0.73 | ALDH1A1 (0.64) | NOTUMALDH1A1L3MBTL1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11780835-B2 | Pyrazolo[3,4-b]pyridine compounds as inhibitors of TAM and MET kinases | ARRAY BIOPHARMA INC. (US) | 2023-10-10 | — | — | US | disclosed |
| US-20230011441-A1 | PYRAZOLO[3,4-b]PYRIDINE COMPOUNDS AS INHIBITORS OF TAM AND MET KINASES | ARRAY BIOPHARMA INC. (US) | 2023-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230011441-A1 | PYRAZOLO[3,4-b]PYRIDINE COMPOUNDS AS INHIBITORS OF TAM AND MET KINASES | RET, MERTK, MET | NOTUM 4690/4885ALDH1A1 2121/4885L3MBTL1 1756/4885 |
| US-11780835-B2 | Pyrazolo[3,4-b]pyridine compounds as inhibitors of TAM and MET kinases | RET, MERTK, MET | NOTUM 4690/4885ALDH1A1 2121/4885L3MBTL1 1756/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.