SCHEMBL3021073

SCHEMBL3021073

Cc1ccc2c(c1)Cc1c(C(=O)NN3CCCCC3)nn(-c3ccc(Cl)cc3Cl)c1-2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ CNR2 P34972 11/20 1.00
▸ CNR1 P21554 6/20 1.00
▸ TDP1 Q9NUW8 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30544878 1.00 CNR2 (1.00) CNR2CNR1TDP1
SCHEMBL14746942 0.94 CNR2 (0.88) CNR2CNR1TDP1
SCHEMBL14746864 0.93 CNR2 (0.86) CNR2CNR1TDP1
SCHEMBL14746878 0.90 CNR2 (0.82) CNR2CNR1TDP1
SCHEMBL14746932 0.90 CNR2 (0.81) CNR2CNR1TDP1
SCHEMBL14742094 0.89 CNR2 (0.81) CNR2CNR1TDP1
SCHEMBL14746913 0.89 CNR2 (0.81) CNR2CNR1TDP1
SCHEMBL16243955 0.89 CNR2 (0.81) CNR2CNR1TDP1
SCHEMBL14746929 0.89 CNR2 (0.81) CNR2CNR1TDP1
SCHEMBL14746853 0.89 CNR2 (0.80) CNR2CNR1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170014355-A1 CANNABINOID RECEPTOR TREATMENTS TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION 2017-01-19 — — US claimed
US-9289421-B2 Methods and compositions for reducing serum levels of immunoglobulin E (IgE) UNIVERSITY OF SOUTH FLORIDA (US) 2016-03-22 — — US claimed
US-20140350052-A1 Methods and Compositions for Reducing Serum Levels of Immunoglobulin E (IGE) NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2014-11-27 — — US claimed
WO-2013033155-A1 METHODS AND COMPOSITIONS FOR REDUCING SERUM LEVELS OF IMMUNOGLOBULIN E (IGE) UNIVERSITY OF SOUTH FLORIA (US) 2013-03-07 — — WO claimed
WO-2013025984-A2 CANNABINOID RECEPTOR TREATMENTS TEMPLE UNIVERSITY (US) 2013-02-21 — — WO claimed
US-20230255970-A1 COMPOSITIONS AND METHODS FOR TREATING PROLIFERATIVE DISEASES THE BROAD INSTITUTE, INC. (US) 2023-08-17 — — US disclosed
US-20180200225-A1 HYDRAZONE MODULATORS OF CANNABINOID RECEPTORS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2018-07-19 — — US disclosed
US-9855225-B2 Cannabinoid receptor treatments TEMPLE UNIVERSITY OFFICE OF TECHNOLOGY TRANSFER (US) 2018-01-02 — — US disclosed
US-20170355959-A1 METHODS FOR MOBILISING POPULATIONS OF STEM CELLS IMPERIAL INNOVATIONS LTD (GB) 2017-12-14 — — US disclosed
US-20170231953-A1 HYDRAZONE MODULATORS OF CANNABINOID RECEPTORS CLEVELAND CLINIC FOUND (US) 2017-08-17 — — US disclosed
US-9656957-B2 Hydrazone modulators of cannabinoid receptors THE CLEVELAND CLINIC FOUNDATION (US) 2017-05-23 — — US disclosed
US-20170014355-A1 CANNABINOID RECEPTOR TREATMENTS TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION 2017-01-19 — — US disclosed
WO-2013025984-A2 CANNABINOID RECEPTOR TREATMENTS TEMPLE UNIVERSITY (US) 2013-02-21 — — WO disclosed
US-8309595-B2 Hydrazone modulators of cannabinoid receptors BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2012-11-13 — — US disclosed
EP-2223913-A1 Tricyclic pyrazole derivatives and microemulsions thereof as CB1- and/or CB2-inhibitors Neuroscienze Pharmaness S.C. A R.L. (IT) 2010-09-01 — — EP disclosed
US-20100216785-A1 PHARMACEUTICAL COMPOSITIONS NEUROSCIENZE PHARMANESS S.C. A.R.L. (IT) 2010-08-26 — — US disclosed
US-20100216785-A1 PHARMACEUTICAL COMPOSITIONS NEUROSCIENZE PHARMANESS S.C. A.R.L. (IT) 2010-08-26 — — US disclosed
US-20100216785-A1 PHARMACEUTICAL COMPOSITIONS NEUROSCIENZE PHARMANESS S.C. A.R.L. (IT) 2010-08-26 — — US disclosed
US-20100197755-A1 HYDRAZONE MODULATORS OF CANNABINOID RECEPTORS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2010-08-05 — — US disclosed
WO-2009012227-A1 HYDRAZONE MODULATORS OF CANNABINOID RECEPTORS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2009-01-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170014355-A1 CANNABINOID RECEPTOR TREATMENTS CNR1, CNR2, GPR18 CNR2 2/4885CNR1 1/4885TDP1 4764/4885
US-20170231953-A1 HYDRAZONE MODULATORS OF CANNABINOID RECEPTORS CNR1, CNR2, GPR18 CNR2 2/4885CNR1 1/4885TDP1 4684/4885
US-20100197755-A1 HYDRAZONE MODULATORS OF CANNABINOID RECEPTORS CNR1, CNR2, GPR18 CNR2 2/4885CNR1 1/4885TDP1 4684/4885
US-20100216785-A1 PHARMACEUTICAL COMPOSITIONS CNR2, CNR1, SGMS2 CNR2 1/4885CNR1 2/4885TDP1 4784/4885
US-20230255970-A1 COMPOSITIONS AND METHODS FOR TREATING PROLIFERATIVE DISEASES YAP1, RELA, NFKBIA CNR2 3876/4885CNR1 3794/4885TDP1 1896/4885
US-20180200225-A1 HYDRAZONE MODULATORS OF CANNABINOID RECEPTORS CNR1, CNR2, GPR18 CNR2 2/4885CNR1 1/4885TDP1 4684/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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