Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.50 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.50 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.42 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | GABRP | O00591 | 2/20 | 0.33 |
| ▸ | GABRD | O14764 | 2/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL3358691 | 1.00 | LMNA (0.56) | LMNAKMT2AMEN1TSHRTP53 | |
| Tromethamine SCHEMBL4449265 | 1.00 | LMNA (0.56) | LMNAKMT2AMEN1TSHRTP53 | |
| Tromethamine SCHEMBL235150 | 1.00 | LMNA (0.56) | LMNAKMT2AMEN1TSHRTP53 | |
| Tromethamine SCHEMBL29379456 | 1.00 | LMNA (0.56) | LMNAKMT2AMEN1TSHRTP53 | |
| Tromethamine SCHEMBL8668436 | 0.82 | LMNA (0.71) | LMNAKMT2AMEN1BLMHTT | |
| Tromethamine SCHEMBL237361 | 0.82 | LMNA (0.71) | LMNAKMT2AMEN1BLMHTT | |
| Tromethamine SCHEMBL9235516 | 0.82 | LMNA (0.71) | LMNAKMT2AMEN1BLMHTT | |
| Tromethamine SCHEMBL4664594 | 0.81 | LMNA (0.53) | LMNAKMT2AMEN1TSHRTP53 | |
| Tromethamine SCHEMBL14876950 | 0.79 | MEN1 (0.67) | LMNAKMT2AMEN1 | |
| Fumaric Acid SCHEMBL22346337 | 0.79 | TSHR (0.45) | LMNAKMT2AMEN1TSHRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023007911-A1 | SUBSTRATE PROCESSING METHOD | 株式会社ＳＣＲＥＥＮホールディングス | 2023-02-02 | — | — | WO | disclosed |