Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.51 |
| ▸ | APAF1 | O14727 | 1/20 | 0.46 |
| ▸ | GRN | P28799 | 2/20 | 0.45 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
| ▸ | MMP1 | P03956 | 2/20 | 0.42 |
| ▸ | MMP3 | P08254 | 2/20 | 0.42 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | CASR | P41180 | 1/20 | 0.42 |
| ▸ | ACP3 | P15309 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30219105 | 1.00 | RIPK1 (0.51) | RIPK1APAF1GRNSORT1POLB | |
| Hydrochloric Acid SCHEMBL30219092 | 0.98 | RIPK1 (0.50) | RIPK1APAF1GRNSORT1POLB | |
| SCHEMBL30903302 | 0.86 | RIPK1 (0.51) | RIPK1GRNSORT1 | |
| Hydrochloric Acid SCHEMBL30168116 | 0.85 | RIPK1 (0.50) | RIPK1GRNSORT1 | |
| SCHEMBL19753552 | 0.83 | MME (0.55) | APAF1POLBCTDSP1CTSKCASR | |
| SCHEMBL15384059 | 0.83 | MME (0.55) | APAF1POLBCTDSP1CTSKCASR | |
| SCHEMBL30219112 | 0.82 | CTSL (0.50) | RIPK1GRNSORT1CTSK | |
| SCHEMBL30219101 | 0.82 | CTSL (0.50) | RIPK1GRNSORT1CTSK | |
| SCHEMBL27505417 | 0.81 | APAF1 (0.53) | APAF1POLBCTDSP1CASRACP3 | |
| SCHEMBL30219104 | 0.81 | RIPK1 (0.46) | RIPK1GRNSORT1MMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4395776-A1 | 2-AMINO-5,5-DIMETHYLHEXANOIC ACID DERIVATIVES AS SORTILIN MODULATORS FOR USE IN THE TREATMENT OF DISEASE OF THE CENTRAL NERVOUS SYSTEM | Insusense ApS (DK) | 2024-07-10 | — | — | EP | claimed |
| WO-2023031440-A1 | 2-AMINO-5,5-DIMETHYLHEXANOIC ACID DERIVATIVES AS SORTILIN MODULATORS FOR USE IN THE TREATMENT OF DISEASE OF THE CENTRAL NERVOUS SYSTEM | INSUSENSE ApS (DK) | 2023-03-09 | — | — | WO | claimed |
| EP-4395776-A1 | 2-AMINO-5,5-DIMETHYLHEXANOIC ACID DERIVATIVES AS SORTILIN MODULATORS FOR USE IN THE TREATMENT OF DISEASE OF THE CENTRAL NERVOUS SYSTEM | Insusense ApS (DK) | 2024-07-10 | — | — | EP | disclosed |
| WO-2023031440-A1 | 2-AMINO-5,5-DIMETHYLHEXANOIC ACID DERIVATIVES AS SORTILIN MODULATORS FOR USE IN THE TREATMENT OF DISEASE OF THE CENTRAL NERVOUS SYSTEM | INSUSENSE ApS (DK) | 2023-03-09 | — | — | WO | disclosed |