Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.46 |
| ▸ | GRN | P28799 | 3/20 | 0.42 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.42 |
| ▸ | PYGL | P06737 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 2/20 | 0.36 |
| ▸ | MMP3 | P08254 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.36 |
| ▸ | PRCP | P42785 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30219068 | 1.00 | RIPK1 (0.46) | RIPK1GRNSORT1PYGLCYP2C9 | |
| SCHEMBL29213449 | 0.84 | MTNR1A (0.44) | GRNSORT1CYP2C9 | |
| SCHEMBL29213492 | 0.84 | MTNR1A (0.44) | GRNSORT1CYP2C9 | |
| SCHEMBL29213263 | 0.84 | MTNR1A (0.44) | GRNSORT1CYP2C9 | |
| SCHEMBL29213259 | 0.84 | MTNR1A (0.44) | GRNSORT1CYP2C9 | |
| SCHEMBL29213261 | 0.84 | MTNR1A (0.44) | GRNSORT1CYP2C9 | |
| SCHEMBL30903302 | 0.82 | RIPK1 (0.51) | RIPK1GRNSORT1PYGLCYP2C9 | |
| SCHEMBL30219101 | 0.82 | CTSL (0.50) | RIPK1GRNSORT1 | |
| SCHEMBL30219112 | 0.82 | CTSL (0.50) | RIPK1GRNSORT1 | |
| Hydrochloric Acid SCHEMBL30168116 | 0.81 | RIPK1 (0.50) | RIPK1GRNSORT1PYGLCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4395776-A1 | 2-AMINO-5,5-DIMETHYLHEXANOIC ACID DERIVATIVES AS SORTILIN MODULATORS FOR USE IN THE TREATMENT OF DISEASE OF THE CENTRAL NERVOUS SYSTEM | Insusense ApS (DK) | 2024-07-10 | — | — | EP | claimed |
| WO-2023031440-A1 | 2-AMINO-5,5-DIMETHYLHEXANOIC ACID DERIVATIVES AS SORTILIN MODULATORS FOR USE IN THE TREATMENT OF DISEASE OF THE CENTRAL NERVOUS SYSTEM | INSUSENSE ApS (DK) | 2023-03-09 | — | — | WO | claimed |
| EP-4395776-A1 | 2-AMINO-5,5-DIMETHYLHEXANOIC ACID DERIVATIVES AS SORTILIN MODULATORS FOR USE IN THE TREATMENT OF DISEASE OF THE CENTRAL NERVOUS SYSTEM | Insusense ApS (DK) | 2024-07-10 | — | — | EP | disclosed |
| WO-2023031440-A1 | 2-AMINO-5,5-DIMETHYLHEXANOIC ACID DERIVATIVES AS SORTILIN MODULATORS FOR USE IN THE TREATMENT OF DISEASE OF THE CENTRAL NERVOUS SYSTEM | INSUSENSE ApS (DK) | 2023-03-09 | — | — | WO | disclosed |