Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | INMT | O95050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16382719 | 0.82 | KDM4E (0.38) | KDM4EAPOBEC3AAPOBEC3GMAPTALDH1A1 | |
| SCHEMBL14981577 | 0.78 | F2RL1 (0.35) | — | |
| SCHEMBL18876106 | 0.75 | F2RL1 (0.42) | KDM4EAPOBEC3AAPOBEC3GMAPT | |
| SCHEMBL18736629 | 0.75 | KDM4E (0.33) | KDM4EAPOBEC3AAPOBEC3GMAPT | |
| SCHEMBL18876196 | 0.75 | HSD11B1 (0.34) | KDM4EAPOBEC3AAPOBEC3GMAPTALDH1A1 | |
| SCHEMBL24981834 | 0.75 | NQO2 (0.35) | KDM4EMAPTALDH1A1 | |
| SCHEMBL2381219 | 0.75 | F2RL1 (0.34) | — | |
| SCHEMBL31500714 | 0.73 | HKDC1 (0.32) | KDM4EMAPTALDH1A1 | |
| SCHEMBL20563046 | 0.73 | ALDH1A1 (0.36) | KDM4EMAPTALDH1A1 | |
| SCHEMBL31271785 | 0.73 | IMPDH2 (0.36) | MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4395776-A1 | 2-AMINO-5,5-DIMETHYLHEXANOIC ACID DERIVATIVES AS SORTILIN MODULATORS FOR USE IN THE TREATMENT OF DISEASE OF THE CENTRAL NERVOUS SYSTEM | Insusense ApS (DK) | 2024-07-10 | — | — | EP | disclosed |
| CN-118019533-A | 2-Amino-5, 5-dimethylhexanoic acid derivatives as sortilin modulators for the treatment of central nervous system diseases | 因苏森斯有限公司 | 2024-05-10 | — | — | CN | disclosed |
| WO-2023031440-A1 | 2-AMINO-5,5-DIMETHYLHEXANOIC ACID DERIVATIVES AS SORTILIN MODULATORS FOR USE IN THE TREATMENT OF DISEASE OF THE CENTRAL NERVOUS SYSTEM | INSUSENSE ApS (DK) | 2023-03-09 | — | — | WO | disclosed |