Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.31 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.31 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.30 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30224671 | 0.87 | KDM4E (0.34) | TRPM5 | |
| SCHEMBL30224922 | 0.83 | AR (0.32) | EPHX2AR | |
| SCHEMBL25004335 | 0.75 | TRPM5 (0.42) | TRPM5PSMD14COPS5SLC40A1PTPN6 | |
| SCHEMBL30224750 | 0.75 | ALDH1A1 (0.40) | — | |
| SCHEMBL20392636 | 0.74 | LPL (0.39) | TRPM5PSMD14COPS5SLC40A1PTPN6 | |
| SCHEMBL30181836 | 0.74 | CHRNB2 (0.44) | AR | |
| SCHEMBL30224864 | 0.74 | CHRNB2 (0.44) | AR | |
| SCHEMBL30181642 | 0.72 | KDM1A (0.54) | — | |
| SCHEMBL30224533 | 0.71 | SLC6A4 (0.50) | — | |
| SCHEMBL30181776 | 0.70 | HTR2C (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4143194-A1 | CD73 INHIBITING 2,4-DIOXOPYRIMIDINE COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2023-03-08 | — | — | EP | disclosed |