Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.67 |
| ▸ | HPGD | P15428 | 5/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.64 |
| ▸ | KCNA3 | P22001 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA3 | P07451 | 1/20 | 0.53 |
| ▸ | CA4 | P22748 | 1/20 | 0.53 |
| ▸ | CA5A | P35218 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14424527 | 0.88 | KDM4E (0.73) | KDM4EALDH1A1HPGDHSD17B10NPC1 | |
| SCHEMBL30231961 | 0.85 | MAPT (0.56) | KDM4EALDH1A1HPGDCYP1A2CYP2C9 | |
| SCHEMBL14424530 | 0.83 | ALDH1A1 (0.58) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 | |
| SCHEMBL30231545 | 0.83 | MAPT (0.57) | KDM4EALDH1A1HPGDHSD17B10KCNA3 | |
| SCHEMBL12227473 | 0.83 | ALDH1A1 (0.68) | KDM4EALDH1A1HPGDHSD17B10NPC1 | |
| SCHEMBL14997043 | 0.83 | ALDH1A1 (0.68) | KDM4EALDH1A1HPGDHSD17B10NPC1 | |
| SCHEMBL30231614 | 0.82 | HPGD (0.60) | KDM4EALDH1A1HPGDKCNA3NPC1 | |
| SCHEMBL30231555 | 0.82 | IGLV6-57 (0.57) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 | |
| SCHEMBL20839139 | 0.82 | KDM4E (0.53) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 | |
| SCHEMBL30763276 | 0.82 | KDM4E (0.53) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023034340-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |
| WO-2023034339-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |