Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | ALPL | P05186 | 2/20 | 0.44 |
| ▸ | ALPG | P10696 | 2/20 | 0.44 |
| ▸ | ALPI | P09923 | 1/20 | 0.44 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29738122 | 0.80 | FGFR1 (0.55) | FGFR1ALPLALPGALPIPLAA | |
| SCHEMBL3838757 | 0.78 | FGFR1 (0.56) | FGFR1ALDH1A1PLA2G4AHPGDHCAR3 | |
| SCHEMBL26672356 | 0.78 | MEN1 (0.56) | FGFR1ALDH1A1KDM4EHTTSMN1; SMN2 | |
| SCHEMBL30497305 | 0.78 | MTNR1A (0.51) | FGFR1ALDH1A1HTTSMN1; SMN2PLA2G4A | |
| SCHEMBL29556127 | 0.78 | MEN1 (0.56) | FGFR1ALDH1A1KDM4EHTTSMN1; SMN2 | |
| SCHEMBL29993514 | 0.77 | FGFR1 (0.49) | FGFR1PLAAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL30782239 | 0.77 | KDM2B (0.51) | FGFR1PLA2G4AHPGDTBXA2RF2 | |
| SCHEMBL2936871 | 0.76 | PLA2G4A (0.49) | FGFR1ALDH1A1KDM4EHTTSMN1; SMN2 | |
| SCHEMBL30686407 | 0.76 | FGFR1 (0.48) | FGFR1ALDH1A1PLA2G4AHPGDHCAR3 | |
| SCHEMBL29649186 | 0.75 | FGFR1 (0.50) | FGFR1ALDH1A1KDM4EHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023057429-A1 | CERTAIN 2,5-DIAZABICYCLO[4.2.0]OCTANES AND OCTAHYDROFURO[3,4- B]PYRAZINES AS GLP-1 RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2023-04-13 | — | — | WO | claimed |
| US-20250115612-A1 | CERTAIN 2,5-DIAZABICYCLO[4.2.0]OCTANES AND OCTAHYDROFURO[3,4-B]PYRAZINES AS GLP-1 RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2025-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250115612-A1 | CERTAIN 2,5-DIAZABICYCLO[4.2.0]OCTANES AND OCTAHYDROFURO[3,4-B]PYRAZINES AS GLP-1 RECEPTOR MODULATORS | GLP1R, GIPR, GPR119 | FGFR1 502/4885ALPL 3551/4885ALPG 3470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.