Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 4/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.35 |
| ▸ | BCHE | P06276 | 6/20 | 0.34 |
| ▸ | ACHE | P22303 | 5/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.33 |
| ▸ | CMA1 | P23946 | 1/20 | 0.33 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.33 |
| ▸ | REN | P00797 | 3/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | APAF1 | O14727 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30278346 | 0.89 | METAP2 (0.35) | NPY5RMETAP2METAP1HTR2CSLC6A4 | |
| SCHEMBL23005049 | 0.87 | NPY5R (0.40) | NPY5RMETAP2METAP1NPSR1CMA1 | |
| SCHEMBL23004827 | 0.86 | NPY5R (0.34) | NPY5RMETAP2METAP1HTR2CSLC6A4 | |
| SCHEMBL30278360 | 0.81 | BCHE (0.41) | NPY5RMETAP2METAP1BCHEACHE | |
| SCHEMBL30278336 | 0.79 | NPY5R (0.41) | NPY5RMETAP2METAP1HTR2CSLC6A4 | |
| SCHEMBL23022839 | 0.78 | ATM (0.47) | NPY5RHTR2CSLC6A4BCHEACHE | |
| SCHEMBL23005058 | 0.76 | METAP2 (0.38) | NPY5RMETAP2METAP1HTR2CNPSR1 | |
| SCHEMBL30278355 | 0.76 | NPY5R (0.39) | NPY5RMETAP2METAP1HTR2CSLC6A4 | |
| SCHEMBL30278364 | 0.72 | GPR119 (0.40) | NPY5RHTR2CSLC6A4ACKR3REN | |
| SCHEMBL23005052 | 0.72 | CTSK (0.47) | CMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230102879-A1 | TRNA SYNTHETASE INHIBITORS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2023-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230102879-A1 | TRNA SYNTHETASE INHIBITORS | TRMT1, AARS1, GARS1 | NPY5R 3819/4885METAP2 819/4885METAP1 619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.