Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23004993 | 1.00 | HTR5A (0.45) | HTR5AMCHR1BRD4CYP2D6RIPK1 | |
| SCHEMBL23005057 | 0.93 | RIPK1 (0.44) | HTR5ABRD4CYP2D6RIPK1CHRM2 | |
| SCHEMBL30278383 | 0.93 | RIPK1 (0.44) | HTR5ABRD4CYP2D6RIPK1CHRM2 | |
| SCHEMBL30278380 | 0.82 | KMT2A (0.44) | BRD4CYP2D6CHRM2CHRM1CHRM3 | |
| SCHEMBL23005034 | 0.82 | KMT2A (0.44) | BRD4CYP2D6CHRM2CHRM1CHRM3 | |
| SCHEMBL23022899 | 0.82 | NPC1 (0.42) | BRD4CYP2D6CHRM2CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL30278350 | 0.81 | KMT2A (0.41) | BRD4CYP2D6CHRM2CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL23004825 | 0.81 | KMT2A (0.41) | BRD4CYP2D6CHRM2CHRM1CHRM3 | |
| SCHEMBL23023124 | 0.76 | CHRM2 (0.59) | CYP2D6CHRM2CHRM1CHRM3BCHE | |
| Hydrochloric Acid SCHEMBL23004932 | 0.75 | CHRM2 (0.58) | CYP2D6CHRM2CHRM1CHRM3BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230102879-A1 | TRNA SYNTHETASE INHIBITORS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2023-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230102879-A1 | TRNA SYNTHETASE INHIBITORS | TRMT1, AARS1, GARS1 | HTR5A 3362/4885MCHR1 3817/4885BRD4 810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.