Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.41 |
| ▸ | HTR5A | P47898 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23005057 | 1.00 | RIPK1 (0.44) | RIPK1CYP2D6CHRM2CHRM1CHRM3 | |
| SCHEMBL23004993 | 0.93 | HTR5A (0.45) | RIPK1CYP2D6CHRM2CHRM1CHRM3 | |
| SCHEMBL30278342 | 0.93 | HTR5A (0.45) | RIPK1CYP2D6CHRM2CHRM1CHRM3 | |
| SCHEMBL30278380 | 0.84 | KMT2A (0.44) | CYP2D6CHRM2CHRM1CHRM3SIGMAR1 | |
| SCHEMBL23022899 | 0.84 | NPC1 (0.42) | CYP2D6CHRM2CHRM1CHRM3SIGMAR1 | |
| SCHEMBL23005034 | 0.84 | KMT2A (0.44) | CYP2D6CHRM2CHRM1CHRM3SIGMAR1 | |
| Hydrochloric Acid SCHEMBL30278350 | 0.83 | KMT2A (0.41) | CYP2D6CHRM2CHRM1CHRM3SIGMAR1 | |
| Hydrochloric Acid SCHEMBL23004825 | 0.83 | KMT2A (0.41) | CYP2D6CHRM2CHRM1CHRM3SIGMAR1 | |
| SCHEMBL23023124 | 0.78 | CHRM2 (0.59) | CYP2D6CHRM2CHRM1CHRM3BCHE | |
| SCHEMBL23022888 | 0.78 | RIPK1 (0.41) | RIPK1BRD4DHFRDCPSP2RX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230102879-A1 | TRNA SYNTHETASE INHIBITORS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2023-03-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230102879-A1 | TRNA SYNTHETASE INHIBITORS | TRMT1, AARS1, GARS1 | RIPK1 3000/4885CYP2D6 3013/4885CHRM2 4851/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.