Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.39 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30279166 | 1.00 | KDM4E (0.45) | KDM4ESMN1; SMN2USP2LMNAMAPK1 | |
| SCHEMBL25073774 | 1.00 | KDM4E (0.45) | KDM4ESMN1; SMN2USP2LMNAMAPK1 | |
| SCHEMBL30279125 | 0.86 | KDM4E (0.45) | KDM4ESMN1; SMN2USP2LMNAMAPK1 | |
| SCHEMBL25073775 | 0.86 | KDM4E (0.45) | KDM4ESMN1; SMN2USP2LMNAMAPK1 | |
| SCHEMBL25073870 | 0.85 | PSMB1 (0.41) | KDM4ESMN1; SMN2USP2LMNAMAPK1 | |
| SCHEMBL30279156 | 0.85 | PSMB1 (0.41) | KDM4ESMN1; SMN2USP2LMNAMAPK1 | |
| SCHEMBL25073875 | 0.81 | PSMB1 (0.44) | KDM4EPSMB1PSMB5 | |
| SCHEMBL31162542 | 0.78 | NLRP3 (0.51) | KDM4ESMN1; SMN2LMNAALDH1A1MAPT | |
| SCHEMBL25073874 | 0.78 | NLRP3 (0.51) | KDM4ESMN1; SMN2LMNAALDH1A1MAPT | |
| SCHEMBL25073776 | 0.78 | KMT2A (0.51) | KDM4ELMNAPSMB1PSMB5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4387963-A1 | PHENYL- AND PYRIDOPYRAZOLE DERIVATIVES AS INHIBITORS OF DDR1 | Redx Pharma Limited (GB) | 2024-06-26 | — | — | EP | disclosed |
| WO-2023021278-A1 | PHENYL- AND PYRIDOPYRAZOLE DERIVATIVES AS INHIBITORS OF DDR1 | REDX PHARMA PLC (GB) | 2023-02-23 | — | — | WO | disclosed |