Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 7/20 | 0.32 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.32 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3031445 | 0.88 | KDM4E (0.34) | SLC6A2SLC6A4SLC6A3CYP19A1KDM4E | |
| SCHEMBL13247040 | 0.81 | ADRA2A (0.45) | CFTRSLC6A2SLC6A4SLC6A3GOPC | |
| SCHEMBL13089119 | 0.79 | SLC6A2 (0.39) | CFTRSLC6A2SLC6A4SLC6A3GOPC | |
| SCHEMBL13089104 | 0.79 | KCNA5 (0.45) | CFTRSLC6A2SLC6A4SLC6A3GOPC | |
| SCHEMBL13089094 | 0.79 | GAA (0.44) | CFTRSLC6A2SLC6A4SLC6A3GOPC | |
| SCHEMBL13089142 | 0.79 | GAA (0.52) | CFTRSLC6A2SLC6A4SLC6A3GOPC | |
| SCHEMBL13089152 | 0.79 | SLC6A2 (0.44) | CFTRSLC6A2SLC6A4SLC6A3GOPC | |
| SCHEMBL13089180 | 0.77 | SLC6A2 (0.61) | CFTRSLC6A2SLC6A4SLC6A3GOPC | |
| SCHEMBL3069737 | 0.77 | CYP19A1 (0.40) | CFTRSLC6A2SLC6A4SLC6A3GOPC | |
| SCHEMBL13247045 | 0.77 | SLC6A3 (0.42) | CFTRSLC6A2SLC6A4SLC6A3GOPC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2162450-B1 | ((BICYLICHETEROARYL) IMIDAZOLYL) METHYLHETEROARYL COMPOUNDS AS ADRENERGIC RECEPTOR AGONISTS | ALLERGAN INC (US) | 2015-02-25 | — | — | EP | disclosed |
| US-8383646-B2 | Therapeutic ((bicylicheteroaryl)imidazolyl) methylheteroaryl compounds | ALLERGAN, INC. (US) | 2013-02-26 | — | — | US | disclosed |
| US-20100190823-A1 | Therapeutic ((Bicylicheteroaryl)Imidazolyl) Methylheteroaryl Compounds | ALLEGERGAN INC. (US) | 2010-07-29 | — | — | US | disclosed |
| EP-2162450-A1 | ((BICYLICHETEROARYL) IMIDAZOLYL) METHYLHETEROARYL COMPOUNDS AS ADRENERGIC RECEPTOR AGONISTS | ALLERGAN, INC. (US) | 2010-03-17 | — | — | EP | disclosed |
| WO-2008147786-A1 | ((BICYLICHETEROARYL) IMIDAZOLYL) METHYLHETEROARYL COMPOUNDS AS ADRENERGIC RECEPTOR AGONISTS | ALLERGAN, INC. (US) | 2008-12-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190823-A1 | Therapeutic ((Bicylicheteroaryl)Imidazolyl) Methylheteroaryl Compounds | OAT, HMGCR, GOT2 | CFTR 540/4885SLC6A2 2777/4885SLC6A4 3302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.