Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 3/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.33 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3031736 | 0.94 | HRH2 (0.36) | JAK1HTR2AHTR2CKDM4EKMT2A | |
| SCHEMBL3031734 | 0.94 | HRH2 (0.36) | JAK1HTR2AHTR2CKDM4EKMT2A | |
| SCHEMBL3027230 | 0.87 | HTR2A (0.37) | JAK1HTR2AHTR2CKDM4EKMT2A | |
| SCHEMBL3028697 | 0.81 | KCNA3 (0.41) | JAK1HTR2AHTR2CKDM4EKMT2A | |
| SCHEMBL14898667 | 0.81 | P2RX7 (0.40) | KDM4EKMT2ATP53 | |
| SCHEMBL13238648 | 0.80 | P2RX7 (0.37) | PTPN11JAK1KDM4EKMT2A | |
| SCHEMBL15436734 | 0.78 | HTR4 (0.32) | PTPN11JAK1 | |
| SCHEMBL14898663 | 0.75 | P2RX7 (0.39) | KDM4EKMT2ATP53 | |
| SCHEMBL3040124 | 0.74 | RAB9A (0.41) | KDM4ETP53RAB9A | |
| SCHEMBL13238646 | 0.74 | P2RX7 (0.41) | JAK1HTR2AKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2096923-B1 | HETEROARYL AMIDE DERIVATIVES | LUNDBECK & CO AS H (DK) | 2014-01-22 | — | — | EP | claimed |
| EP-2096923-B1 | HETEROARYL AMIDE DERIVATIVES | LUNDBECK & CO AS H (DK) | 2014-01-22 | — | — | EP | disclosed |
| US-20130172549-A1 | Heteroaryl amide derivatives | H. LUNDBECK A/S (DK) | 2013-07-04 | — | — | US | disclosed |
| EP-2591675-A1 | Heteroaryl amide derivatives | H. Lundbeck A/S (DK) | 2013-05-15 | — | — | EP | disclosed |
| US-8431593-B2 | Heteroaryl amide derivatives | H. LUNDBECK A/S (DK) | 2013-04-30 | — | — | US | disclosed |
| US-20100216763-A1 | Heteroaryl Amide Derivatives | H. LUNDBECK A/S (DK) | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216763-A1 | Heteroaryl Amide Derivatives | HCAR2, PIGS, GPR52 | PTPN11 3838/4885JAK1 3201/4885SLC6A1 2160/4885 |
| US-20130172549-A1 | Heteroaryl amide derivatives | HCAR2, PIGS, GPR52 | PTPN11 3838/4885JAK1 3201/4885SLC6A1 2160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.