Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | CTSL | P07711 | 1/20 | 0.59 |
| ▸ | CTSB | P07858 | 1/20 | 0.59 |
| ▸ | CTSK | P43235 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | TGM2 | P21980 | 1/20 | 0.55 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.55 |
| ▸ | DPP4 | P27487 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5122686 | 0.88 | TGM2 (0.67) | ALDH1A1GAACTSLCTSBCTSK | |
| SCHEMBL7394267 | 0.88 | TSHR (0.62) | ALDH1A1GAACTSLCTSBCTSK | |
| SCHEMBL11960651 | 0.85 | ALDH1A1 (0.58) | ALDH1A1GAACTSLCTSBCTSK | |
| SCHEMBL30289124 | 0.85 | ALDH1A1 (0.64) | ALDH1A1GAACTSLCTSBCTSK | |
| SCHEMBL13402357 | 0.84 | ALDH1A1 (0.67) | ALDH1A1GAACTSLCTSBCTSK | |
| SCHEMBL5692127 | 0.84 | CTSL (0.67) | ALDH1A1GAACTSLCTSBCTSK | |
| SCHEMBL27872787 | 0.83 | BCHE (0.58) | ALDH1A1GAACTSLCTSBCTSK | |
| SCHEMBL5854461 | 0.83 | ALDH1A1 (0.56) | ALDH1A1GAACTSLCTSBCTSK | |
| SCHEMBL31065853 | 0.83 | SIGMAR1 (0.70) | ALDH1A1GAACTSLCTSBCTSK | |
| SCHEMBL27889140 | 0.82 | SIGMAR1 (0.60) | ALDH1A1GAACTSLCTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4405359-A2 | MDM2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-07-31 | — | — | EP | disclosed |
| WO-2023049790-A2 | MDM2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-03-30 | — | — | WO | disclosed |