Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hippuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.56 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | PTPRC | P08575 | 2/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.49 |
| ▸ | USP5 | P45974 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hippuric Acid SCHEMBL2405067 | 1.00 | KDM4E (0.56) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL2464569 | 0.95 | KDM4E (0.56) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| SCHEMBL22030672 | 0.89 | GAA (0.68) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL7486 | 0.89 | GAA (0.68) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL428479 | 0.89 | GAA (0.68) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL1609915 | 0.87 | NPC1 (0.49) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL11709120 | 0.87 | MAPT (0.66) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL21569381 | 0.87 | MAPT (0.66) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL8165809 | 0.87 | MAPT (0.66) | KDM4EMAPTHIF1ASLC22A6SLC22A8 | |
| Hippuric Acid SCHEMBL15416338 | 0.87 | MAPT (0.66) | KDM4EMAPTHIF1ASLC22A6SLC22A8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3948 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240282425-A1 | AUTHENTICATION METHODS AND SYSTEMS FOR DISPENSED PRESCRIPTIONS | LOW GORDON KEITH (US) | 2024-08-22 | — | — | US | claimed |
| WO-2024015331-A1 | THERAPEUTIC AND DIAGNOSTIC METHODS FOR MULTIPLE SCLEROSIS | GENENTECH, INC. (US) | 2024-01-18 | — | — | WO | claimed |
| US-11766464-B2 | Method for gut mucosa preparation to enhance microbial engraftment | MILIS ANTONY (AU) | 2023-09-26 | — | — | US | claimed |
| CN-115297859-A | Devices, compositions and methods for colonic microbiota transplantation | 托马斯·朱利叶斯·波洛迪 | 2022-11-04 | — | — | CN | claimed |
| US-20220233437-A1 | DEVICES, COMPOSITIONS AND METHODS FOR COLONIC MICROBIOME ENGRAFTMENT | BORODY THOMAS J (AU) | 2022-07-28 | — | — | US | claimed |
| US-20220226399-A1 | METHOD FOR GUT MUCOSA PREPARATION TO ENHANCE MICROBIAL ENGRAFTMENT | MILIS ANTONY (AU) | 2022-07-21 | — | — | US | claimed |
| US-20220169680-A1 | CELL-PENETRATING PEPTIDE BASED ON INFLUENZA VIRUS M2 PROTEIN | INSTITUTE OF BASIC MEDICAL SCIENCES CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2022-06-02 | — | — | US | claimed |
| EP-3996727-A1 | METHOD FOR GUT MUCOSA PREPARATION TO ENHANCE MICROBIAL ENGRAFTMENT | Milis, Antony (AU) | 2022-05-18 | — | — | EP | claimed |
| CN-114364388-A | Preparation method of intestinal mucosa for enhancing microbial implantation | 安东尼·米利斯 | 2022-04-15 | — | — | CN | claimed |
| EP-3976030-A1 | DEVICES, COMPOSITIONS AND METHODS FOR COLONIC MICROBIOME ENGRAFTMENT | Borody, Thomas Julius (AU) | 2022-04-06 | — | — | EP | claimed |
| US-5780049-A | Enhanced skin penetration system for improved topical delivery of drugs | RICHARDSON-VICKS INC. (US) | 1998-07-14 | — | — | US | claimed |
| EP-0792371-A1 | COMBINATION METHOD FOR ACNE TREATMENT | Merck & Co., Inc. (US) | 1997-09-03 | — | — | EP | claimed |
| EP-0786999-A1 | COMBINATION METHOD FOR ACNE TREATMENT | Merck & Co., Inc. (US) | 1997-08-06 | — | — | EP | claimed |
| WO-1997009973-A2 | PERIPHERALLY ACTIVE ANTI-HYPERALGESIC OPIATES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-03-20 | — | — | WO | claimed |
| US-5543417-A | 5 Alpha-reductase inhibitor and at least one of an antibacterial agent, a keratolytic agent or an anti-inflammatory agent | MERCK & CO., INC. (US) | 1996-08-06 | — | — | US | claimed |
| WO-1996012487-A1 | COMBINATION METHOD FOR ACNE TREATMENT | MERCK & CO., INC. (US) | 1996-05-02 | — | — | WO | claimed |
| WO-1996012817-A1 | COMBINATION METHOD FOR ACNE TREATMENT | MERCK & CO., INC. (US) | 1996-05-02 | — | — | WO | claimed |
| US-5357636-A | Flexible protective medical gloves and methods for their use | DRESDNER JR KARL P (US) | 1994-10-25 | — | — | US | claimed |
| US-4952402-A | EDIBLE TASTE-MASKED DRUGS; MICROMATRIX ACTIVE MATERIAL COATED WITH NONTOXIC POLYMER; LIQUIDS; TABLETS | ELAN CORPORATION, P.L.C. (IE) | 1990-08-28 | — | — | US | claimed |
| US-4369172-A | Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose | FOREST LABORATORIES INC. (US) | 1983-01-18 | — | — | US | claimed |