Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hippuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.44 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.44 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.43 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.43 |
| ▸ | PTPRC | P08575 | 2/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hippuric Acid SCHEMBL31448705 | 0.92 | LMNA (0.58) | NPC1RAB9ASMN1; SMN2LMNAMAPK1 | |
| Hippuric Acid SCHEMBL2405067 | 0.87 | KDM4E (0.56) | NPC1RAB9ASMN1; SMN2LMNAMAPK1 | |
| Hippuric Acid SCHEMBL3029 | 0.87 | KDM4E (0.56) | NPC1RAB9ASMN1; SMN2LMNAMAPK1 | |
| Hippuric Acid SCHEMBL2464569 | 0.83 | KDM4E (0.56) | RAB9ASMN1; SMN2MAPK1GPR139KDM4E | |
| Mandelic Acid SCHEMBL3645 | 0.81 | LMNA (0.75) | NPC1SMN1; SMN2LMNAMAPK1KDM4E | |
| Mandelic Acid SCHEMBL9747772 | 0.81 | LMNA (0.75) | NPC1SMN1; SMN2LMNAMAPK1KDM4E | |
| Mandelic Acid SCHEMBL388417 | 0.79 | LMNA (0.72) | NPC1SMN1; SMN2LMNAMAPK1KDM4E | |
| Hippuric Acid SCHEMBL428479 | 0.77 | GAA (0.68) | NPC1RAB9ASMN1; SMN2LMNAGPR139 | |
| SCHEMBL22030672 | 0.77 | GAA (0.68) | NPC1RAB9ASMN1; SMN2LMNAGPR139 | |
| Hippuric Acid SCHEMBL7486 | 0.77 | GAA (0.68) | NPC1RAB9ASMN1; SMN2LMNAGPR139 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110087009-A1 | PROCESS FOR THE CONTROLLED PRODUCTION OF ORGANIC PARTICLES | YUN SUNG LAI JIMMY | 2011-04-14 | — | — | US | disclosed |
| US-7875295-B2 | High shear precipitation; faster, higher yield of microparticles or nanoparticles | NANOMATERIALS TECHNOLOGY PTE LTD (SG) | 2011-01-25 | — | — | US | disclosed |
| US-20080212402-A1 | Process for the controlled production of organic particles | YUN SUNG LAI JIMMY | 2008-09-04 | — | — | US | disclosed |
| EP-0935460-B1 | TASTE MASKED PHARMACEUTICAL COMPOSITIONS | FAULDING F H & CO LTD (AU) | 2004-11-10 | — | — | EP | disclosed |
| US-20040191319-A1 | Process for the controlled production of organic particles | NMT PHARMACEUTICALS PTE LTD (SG) | 2004-09-30 | — | — | US | disclosed |
| US-20030064108-A1 | TASTE MASKED PHARMACEUTICAL COMPOSITIONS | FH FAULDING & CO. LIMITED (AU) | 2003-04-03 | — | — | US | disclosed |
| WO-2002089970-A1 | PROCESS FOR THE CONTROLLED PRODUCTION OF ORGANIC PARTICLES | NANOMATERIALS TECHNOLOGY PTE LTD (SG) | 2002-11-14 | — | — | WO | disclosed |
| EP-0935460-A4 | TASTE MASKED PHARMACEUTICAL COMPOSITIONS | FAULDING F H & CO LTD (AU) | 1999-12-22 | — | — | EP | disclosed |
| EP-0935460-A1 | TASTE MASKED PHARMACEUTICAL COMPOSITIONS | F.H. FAULDING & CO. LIMITED (AU) | 1999-08-18 | — | — | EP | disclosed |
| WO-1998047493-A1 | TASTE MASKED PHARMACEUTICAL COMPOSITIONS | F.H. FAULDING & CO. LIMITED (AU) | 1998-10-29 | — | — | WO | disclosed |