Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 16/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | XBP1 | P17861 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8689527 | 0.89 | ALDH1A1 (0.69) | ALOX15ALDH1A1CYP1A2HPGDXBP1 | |
| SCHEMBL4042096 | 0.89 | ALOX15 (0.74) | ALOX15ALDH1A1CYP1A2HPGDXBP1 | |
| SCHEMBL8793660 | 0.87 | ALOX15 (0.85) | ALOX15ALDH1A1CYP1A2HPGDXBP1 | |
| SCHEMBL26213307 | 0.86 | ALOX15 (0.70) | ALOX15ALDH1A1CYP1A2HPGDXBP1 | |
| SCHEMBL14174311 | 0.86 | ALOX15 (0.70) | ALOX15ALDH1A1CYP1A2HPGDXBP1 | |
| SCHEMBL4358217 | 0.85 | ALOX15 (0.81) | ALOX15ALDH1A1CYP1A2HPGDXBP1 | |
| SCHEMBL4045222 | 0.85 | ALOX15 (0.69) | ALOX15ALDH1A1CYP1A2HPGDXBP1 | |
| SCHEMBL11559665 | 0.84 | ALDH1A1 (0.70) | ALOX15ALDH1A1CYP1A2HPGDXBP1 | |
| SCHEMBL4573082 | 0.84 | ALOX15 (0.67) | ALOX15 | |
| SCHEMBL469602 | 0.84 | ALOX15 (1.00) | ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304419-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2012-11-06 | — | — | US | disclosed |
| US-20100216746-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216746-A1 | CHEMICAL COMPOUNDS | SAMHD1, POLRMT, NUDT1 | ALOX15 1278/4885ALDH1A1 348/4885CYP1A2 301/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.