Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3029444 | 1.00 | NPC1 (0.46) | NPC1L3MBTL1TDP1MAPTRAB9A | |
| SCHEMBL1395649 | 0.82 | NPC1 (0.54) | NPC1L3MBTL1MAPTALDH1A1KMT2A | |
| SCHEMBL1630772 | 0.82 | NPC1 (0.54) | NPC1L3MBTL1MAPTALDH1A1KMT2A | |
| SCHEMBL1022195 | 0.82 | NPC1 (0.54) | NPC1L3MBTL1MAPTALDH1A1KMT2A | |
| SCHEMBL20143905 | 0.77 | NPC1 (0.40) | NPC1L3MBTL1ALDH1A1LMNATRPM8 | |
| SCHEMBL4787589 | 0.75 | NPC1 (0.48) | NPC1L3MBTL1ALDH1A1KMT2ALMNA | |
| SCHEMBL104713 | 0.75 | NPC1 (0.48) | NPC1L3MBTL1KMT2ALMNATRPM8 | |
| SCHEMBL15931520 | 0.75 | NPC1 (0.48) | NPC1L3MBTL1ALDH1A1KMT2ALMNA | |
| SCHEMBL104712 | 0.75 | NPC1 (0.48) | NPC1L3MBTL1KMT2ALMNATRPM8 | |
| SCHEMBL3040815 | 0.74 | TDP1 (0.48) | NPC1L3MBTL1TDP1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2195284-B1 | PROCESS FOR PREPARING 2-DIHALOACYL-3-AMINOACRYLIC ACID DERIVATIVES | BAYER IP GMBH (DE) | 2017-03-22 | — | — | EP | claimed |
| EP-2245001-B1 | Method for the production of 2-fluoroacyl-3-amino-acrylic acid derivatives | BAYER CROPSCIENCE AG (DE) | 2013-03-20 | — | — | EP | claimed |
| US-8288582-B2 | Method for the production of 2-fluoroacyl-3-aminoacrylic acid derivatives | BAYER CROPSCIENCE AG (DE) | 2012-10-16 | — | — | US | claimed |
| US-8258335-B2 | Process for preparing 2-dihaloacyl-3-aminoacrylic acid derivatives | BAYER CROPSCIENCE AG (DE) | 2012-09-04 | — | — | US | claimed |
| EP-2245001-A1 | METHOD FOR THE PRODUCTION OF 2-FLUOROACYL-3-AMINO-ACRYLIC ACID DERIVATIVES | Bayer CropScience AG (DE) | 2010-11-03 | — | — | EP | claimed |
| US-20100274049-A1 | Method for the production of 2-fluoroacyl-3-aminoacrylic acid derivatives | BAYER CROPSCIENCE AG (DE) | 2010-10-28 | — | — | US | claimed |
| US-20100204483-A1 | PROCESS FOR PREPARING 2-DIHALOACYL-3-AMINOACRYLIC ACID DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2010-08-12 | — | — | US | claimed |
| EP-2195284-A1 | PROCESS FOR PREPARING 2-DIHALOACYL-3-AMINOACRYLIC ACID DERIVATIVES | Bayer CropScience AG (DE) | 2010-06-16 | — | — | EP | claimed |
| WO-2009083134-A1 | METHOD FOR THE PRODUCTION OF 2-FLUOROACYL-3-AMINO-ACRYLIC ACID DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2009-07-09 | — | — | WO | claimed |
| EP-2072497-A1 | Method for manufacturing 2-fluoracyl-3-amino-acrylic acid derivatives | Bayer CropScience AG (DE) | 2009-06-24 | — | — | EP | claimed |
| WO-2009043444-A1 | PROCESS FOR PREPARING 2-DIHALOACYL-3-AMINOACRYLIC ACID DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2009-04-09 | — | — | WO | claimed |
| EP-2042482-A1 | Method for manufacturing 2-dihalogenacyl-3-amino-acrylic acid derivatives | Bayer CropScience AG (DE) | 2009-04-01 | — | — | EP | claimed |
| EP-2195284-B1 | PROCESS FOR PREPARING 2-DIHALOACYL-3-AMINOACRYLIC ACID DERIVATIVES | BAYER IP GMBH (DE) | 2017-03-22 | — | — | EP | disclosed |
| EP-2245001-B1 | Method for the production of 2-fluoroacyl-3-amino-acrylic acid derivatives | BAYER CROPSCIENCE AG (DE) | 2013-03-20 | — | — | EP | disclosed |
| US-8288582-B2 | Method for the production of 2-fluoroacyl-3-aminoacrylic acid derivatives | BAYER CROPSCIENCE AG (DE) | 2012-10-16 | — | — | US | disclosed |
| US-8258335-B2 | Process for preparing 2-dihaloacyl-3-aminoacrylic acid derivatives | BAYER CROPSCIENCE AG (DE) | 2012-09-04 | — | — | US | disclosed |
| EP-2057126-A2 | PROCESS FOR PREPARING 3-DIHALOMETHYLPYRAZOLE-4-CARBOXYLIC ACID DERIVATIVES | Bayer CropScience AG (DE) | 2009-05-13 | — | — | EP | disclosed |
| WO-2009043444-A1 | PROCESS FOR PREPARING 2-DIHALOACYL-3-AMINOACRYLIC ACID DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2009-04-09 | — | — | WO | disclosed |
| EP-2042482-A1 | Method for manufacturing 2-dihalogenacyl-3-amino-acrylic acid derivatives | Bayer CropScience AG (DE) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008022777-A2 | PROCESS FOR PREPARING 3-DIHALOMETHYLPYRAZOLE-4-CARBOXYLIC ACID DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2008-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204483-A1 | PROCESS FOR PREPARING 2-DIHALOACYL-3-AMINOACRYLIC ACID DERIVATIVES | AADAT, DDC, IDUA | NPC1 4187/4885L3MBTL1 4735/4885TDP1 1688/4885 |
| US-20100274049-A1 | Method for the production of 2-fluoroacyl-3-aminoacrylic acid derivatives | AADAT, AADAC, ALAD | NPC1 4700/4885L3MBTL1 4296/4885TDP1 2572/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.