Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 2/20 | 0.33 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.32 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 2/20 | 0.32 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19286068 | 0.93 | GPR84 (0.37) | ALOX5CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL1687703 | 0.88 | ALOX5 (0.40) | ALOX5CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL7874405 | 0.79 | — | — | |
| SCHEMBL14516277 | 0.79 | NR1I2 (0.41) | ALOX5CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL12193852 | 0.79 | CHRNB2 (0.34) | ALOX5CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL11956274 | 0.78 | ALOX5 (0.42) | ALOX5CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL27408998 | 0.78 | NR1I2 (0.40) | ALOX5CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL6685021 | 0.77 | RIPK1 (0.40) | RIPK1POLBBDKRB2 | |
| SCHEMBL14288462 | 0.77 | SIGMAR1 (0.46) | IDO1TDO2POLBSLC6A2 | |
| SCHEMBL22166101 | 0.76 | NR1I2 (0.41) | ALOX5CHRNB2CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3360869-B1 | HALOGEN-SUBSTITUTED HETEROCYCLIC COMPOUND USEFUL FOR THE TREATMENT OF DISEASES CAUSED BY LPA. | UBE INDUSTRIES (JP) | 2020-07-29 | — | — | EP | disclosed |
| CN-101679344-B | Method for the production of substituted heteroaromates | SALTIGO GMBH | 2013-04-24 | — | — | CN | disclosed |
| US-8258314-B2 | Process for the preparation of substituted heteroaromatics | SALTIGO GMBH (US) | 2012-09-04 | — | — | US | disclosed |
| EP-2158193-B1 | METHOD FOR THE PRODUCTION OF ALKYL-SUBSTITUTED THIOPHENES | SALTIGO GMBH (DE) | 2012-08-08 | — | — | EP | disclosed |
| US-20100217015-A1 | Process for the preparation of substituted heteroaromatics | SALTIGO GMBH (DE) | 2010-08-26 | — | — | US | disclosed |
| CN-101679344-A | Method for the production of substituted heteroaromates | SALTIGO GMBH | 2010-03-24 | — | — | CN | disclosed |
| EP-2158193-A1 | METHOD FOR THE PRODUCTION OF SUBSTITUTED HETEROAROMATES | Saltigo GmbH (DE) | 2010-03-03 | — | — | EP | disclosed |
| WO-2008151920-A1 | METHOD FOR THE PRODUCTION OF SUBSTITUTED HETEROAROMATES | SALTIGO GMBH (DE) | 2008-12-18 | — | — | WO | disclosed |
| EP-1836184-B1 | IMPROVED PROCESS FOR THE KUMADA COUPLING REACTION | HONEYWELL INT INC (US) | 2008-06-04 | — | — | EP | disclosed |
| EP-1836184-A1 | IMPROVED PROCESS FOR THE KUMADA COUPLING REACTION | Honeywell International Inc. (US) | 2007-09-26 | — | — | EP | disclosed |
| US-7205414-B2 | Process for the Kumada coupling reaction | HONEYWELL INTERNATIONAL INC. (US) | 2007-04-17 | — | — | US | disclosed |
| WO-2006076150-A1 | IMPROVED PROCESS FOR THE KUMADA COUPLING REACTION | HONEYWELL INTERNATIONAL INC. (US) | 2006-07-20 | — | — | WO | disclosed |
| US-20060155134-A1 | Process for the kumada coupling reaction | HONEYWELL INTERNATIONAL INC. | 2006-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100217015-A1 | Process for the preparation of substituted heteroaromatics | CBR3, KCNA5, KAT5 | ALOX5 192/4885CHRNB2 3043/4885CHRNB4 1876/4885 |
| US-20060155134-A1 | Process for the kumada coupling reaction | KMT5A, KMT5C, KCNT1 | ALOX5 1129/4885CHRNB2 4422/4885CHRNB4 3780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.