Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.39 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10473152 | 0.81 | ADRB2 (0.44) | POLBALDH1A1ATMTDP1HPGD | |
| SCHEMBL30297993 | 0.80 | ELANE (0.39) | POLBALDH1A1ATMTDP1HPGD | |
| SCHEMBL7582040 | 0.75 | ADRB2 (0.44) | POLBALDH1A1ATMTDP1HPGD | |
| SCHEMBL11289462 | 0.75 | POLB (0.53) | POLBALDH1A1TDP1HPGDKMT2A | |
| SCHEMBL3977245 | 0.75 | ALDH1A1 (0.53) | POLBALDH1A1TDP1HPGDKMT2A | |
| SCHEMBL30181075 | 0.74 | NPC1 (0.44) | POLBALDH1A1TDP1KMT2AMAPT | |
| SCHEMBL31310726 | 0.73 | LMNA (0.54) | POLBALDH1A1ATMTDP1HPGD | |
| SCHEMBL31310725 | 0.73 | LMNA (0.72) | POLBALDH1A1TDP1HPGDKMT2A | |
| SCHEMBL30954831 | 0.73 | CSF1R (0.41) | POLBALDH1A1HPGDKMT2AMAPT | |
| SCHEMBL30297987 | 0.73 | CSF1R (0.41) | POLBALDH1A1HPGDKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4399206-A1 | PAPD5 AND/OR PAPD7 INHIBITING 4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID DERIVATIVES | Redona Therapeutics, Inc. (US) | 2024-07-17 | — | — | EP | disclosed |
| CN-118201914-A | 4-Oxo-1, 4-dihydroquinoline-3-carboxylic acid derivatives as PAPD5 and/or PAPD7 inhibitors | 雷多纳治疗公司 | 2024-06-14 | — | — | CN | disclosed |
| WO-2023039089-A1 | PAPD5 AND/OR PAPD7 INHIBITING 4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID DERIVATIVES | TWENTYEIGHT-SEVEN, INC. (US) | 2023-03-16 | — | — | WO | disclosed |