Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.59 |
| ▸ | NOS2 | P35228 | 1/20 | 0.59 |
| ▸ | MAOA | P21397 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | HTR5A | P47898 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29385430 | 1.00 | NOS3 (0.59) | NOS3NOS2MAOAKDM4EALDH1A1 | |
| Iodide SCHEMBL8204922 | 0.82 | NOS3 (0.42) | NOS3NOS2MAOAKDM4EALDH1A1 | |
| SCHEMBL7650854 | 0.80 | ALDH1A1 (0.46) | NOS3NOS2MAOAKDM4EALDH1A1 | |
| SCHEMBL8603671 | 0.79 | ALDH1A1 (0.44) | NOS3NOS2MAOAKDM4EALDH1A1 | |
| SCHEMBL8170948 | 0.77 | TSHR (0.54) | NOS3NOS2MAOAKDM4EALDH1A1 | |
| SCHEMBL6207612 | 0.76 | NOS3 (0.52) | NOS3NOS2MAOAKDM4EALDH1A1 | |
| SCHEMBL29498353 | 0.76 | NOS3 (0.52) | NOS3NOS2MAOAKDM4EALDH1A1 | |
| SCHEMBL1009906 | 0.75 | MAOA (0.53) | NOS3NOS2MAOAKDM4EALDH1A1 | |
| SCHEMBL2616773 | 0.75 | MAOA (0.53) | NOS3NOS2MAOAKDM4EALDH1A1 | |
| SCHEMBL29361631 | 0.75 | KDM4E (0.60) | NOS3NOS2MAOAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 224 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117326975-A | O-allyl oxime ester photoinitiating compound, and preparation method and application thereof | 同济大学 | 2024-01-02 | — | — | CN | claimed |
| CN-107001278-A | Tetrahydro isoquinoline derivative | UCB生物制药私人有限公司 | 2017-08-01 | — | — | CN | claimed |
| CN-106660955-A | Cyclohexene derivative, preparation method therefor, and pharmaceutical composition for preventing or treating metabolic diseases, containing same as active ingredient | 现代药品株式会社 | 2017-05-10 | — | — | CN | claimed |
| CN-102093346-B | Preparation method of praziquantel | ZHEJIANG GENEBEST PHARMACEUTICAL CO LTD | 2012-09-05 | — | — | CN | claimed |
| CN-102093346-A | Preparation method of praziquantel | ZHEJIANG GENEBEST PHARMACEUTICAL CO LTD | 2011-06-15 | — | — | CN | claimed |
| EP-1200410-A1 | ISOQUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND A PROCESS FOR THE PREPARATION OF THE ACTIVE SUBSTANCE | Egis Gyogyszergyar Rt. (HU) | 2002-05-02 | — | — | EP | claimed |
| WO-2001009101-A1 | ISOQUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND A PROCESS FOR THE PREPARATION OF THE ACTIVE SUBSTANCE | EGIS Gyógyszergyár Rt. (HU) | 2001-02-08 | — | — | WO | claimed |
| EP-0143333-B1 | [Bis(hydroxymethyl)-methyl]-isoquinoline derivatives, process for preparing them and pharmaceutical compositions containing them | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1988-06-01 | — | — | EP | claimed |
| EP-0143333-A1 | [Bis(hydroxymethyl)-methyl]-isoquinoline derivatives, process for preparing them and pharmaceutical compositions containing them | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1985-06-05 | — | — | EP | claimed |
| US-20250059209-A1 | THERAPEUTIC AGENTS AND USES THEREOF | ANKH LIFE SCIENCES LIMITED (IE) | 2025-02-20 | — | — | US | disclosed |
| US-12129265-B2 | Therapeutic agents and uses thereof | ANKH LIFE SCIENCES LIMITED (IE) | 2024-10-29 | — | — | US | disclosed |
| CN-117326975-A | O-allyl oxime ester photoinitiating compound, and preparation method and application thereof | 同济大学 | 2024-01-02 | — | — | CN | disclosed |
| EP-4263511-A1 | NOVEL BIFUNCTIONAL MOLECULES FOR TARGETED PROTEIN DEGRADATION | Amphista Therapeutics Ltd (GB) | 2023-10-25 | — | — | EP | disclosed |
| EP-4185288-A1 | THERAPEUTIC AGENTS AND USES THEREOF | Ankh Life Sciences Limited (IE) | 2023-05-31 | — | — | EP | disclosed |
| US-4623647-A | ANTIDEPRESSANT, ANTISECRETORY, ANALGESIC, IMMUNOSUPPESSIVE | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1986-11-18 | — | — | US | disclosed |
| US-4622327-A | ANALGESICS, ANTIPYRETICS | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1986-11-11 | — | — | US | disclosed |
| EP-0153994-A1 | (Bis(substituted methyl)-methyl)-isoquinoline derivatives, process for their preparation and pharmaceutical compositions containing them | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1985-09-11 | — | — | EP | disclosed |
| EP-0143333-A1 | [Bis(hydroxymethyl)-methyl]-isoquinoline derivatives, process for preparing them and pharmaceutical compositions containing them | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1985-06-05 | — | — | EP | disclosed |
| EP-0142740-A1 | N-substituted [bis(hydroxymethyl)-methyl]-isoquinoline derivatives, process for preparing them and pharmaceutical compositions containing them | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 1985-05-29 | — | — | EP | disclosed |
| EP-0130729-A2 | Alkylthio- and alkylsulfinyl-benzimidazole derivatives | THE UPJOHN COMPANY (US) | 1985-01-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250059209-A1 | THERAPEUTIC AGENTS AND USES THEREOF | MCL1, RNASE1, HNMT | NOS3 2653/4885NOS2 3574/4885MAOA 115/4885 |
| US-12129265-B2 | Therapeutic agents and uses thereof | MCL1, BCL9, RNASE1 | NOS3 2951/4885NOS2 3668/4885MAOA 74/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.