Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 2/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | SCN4A | P35499 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22346775 | 0.86 | ALDH1A1 (0.56) | KMT2AKDM4EDHFRCES2ALDH1A1 | |
| SCHEMBL22955472 | 0.79 | TGFBR1 (0.49) | KMT2AKDM4ETGFBR1ALDH1A1HPGD | |
| SCHEMBL30387658 | 0.78 | BACE1 (0.58) | KMT2ABACE1SCN9A | |
| SCHEMBL27902504 | 0.78 | BACE1 (0.58) | KMT2ABACE1SCN9A | |
| SCHEMBL31603641 | 0.76 | TGFBR1 (0.43) | KDM4ETGFBR1ALDH1A1HPGDALOX15 | |
| SCHEMBL27244259 | 0.76 | HPGDS (0.57) | KMT2AKDM4EPARP1BACE1MAPK1 | |
| SCHEMBL7449066 | 0.76 | KMT2A (0.47) | KMT2AKDM4EPARP1BACE1MAPK1 | |
| SCHEMBL5679852 | 0.76 | BACE1 (0.59) | KDM4EBACE1EPHX2SCN4A | |
| SCHEMBL10849169 | 0.76 | KDM4E (0.59) | KDM4EPARP1BACE1DHFRCES2 | |
| Trifluoroacetic Acid SCHEMBL5480884 | 0.74 | ALDH1A1 (0.60) | KDM4ETGFBR1ALDH1A1HPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11958840-B2 | Compounds, compositions and methods | DENALI THERAPEUTICS INC. (US) | 2024-04-16 | — | — | US | disclosed |
| US-20230114472-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | DENALI THERAPEUTICS INC. | 2023-04-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11958840-B2 | Compounds, compositions and methods | EIF4EBP1, EIF4B, EIF4E | KMT2A 3876/4885KDM4E 2319/4885PARP1 1400/4885 |
| US-20230114472-A1 | COMPOUNDS, COMPOSITIONS AND METHODS | EIF4EBP1, EIF4B, EIF4E | KMT2A 3876/4885KDM4E 2319/4885PARP1 1400/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.