Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | NQO2 | P16083 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12927928 | 1.00 | MAPT (0.56) | MAPTALDH1A1HSD17B10CYP1A2RAB9A | |
| SCHEMBL24146774 | 0.88 | MTNR1A (0.51) | MAPTALDH1A1HSD17B10CYP1A2RAB9A | |
| SCHEMBL24146776 | 0.88 | MAPT (0.46) | MAPTALDH1A1HSD17B10CYP1A2RAB9A | |
| SCHEMBL24146775 | 0.87 | NPSR1 (0.50) | MAPTALDH1A1HSD17B10CYP1A2RAB9A | |
| SCHEMBL24147284 | 0.86 | LMNA (0.51) | MAPTALDH1A1HSD17B10CYP1A2L3MBTL1 | |
| SCHEMBL2921891 | 0.85 | ALDH1A1 (0.57) | MAPTALDH1A1HSD17B10CYP1A2RAB9A | |
| SCHEMBL12948561 | 0.85 | GPR35 (0.43) | MAPTALDH1A1HSD17B10RAB9APOLB | |
| SCHEMBL11428932 | 0.83 | RAB9A (0.58) | MAPTALDH1A1CYP1A2RAB9APOLB | |
| SCHEMBL10494613 | 0.81 | MAPT (0.72) | MAPTALDH1A1HSD17B10CYP1A2RAB9A | |
| SCHEMBL10494616 | 0.81 | MAPT (0.72) | MAPTALDH1A1HSD17B10CYP1A2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4405346-A2 | SMALL MOLECULE INHIBITORS OF TEAD-YAP | The General Hospital Corporation (US) | 2024-07-31 | — | — | EP | disclosed |
| WO-2023049808-A2 | SMALL MOLECULE INHIBITORS OF TEAD-YAP | THE GENERAL HOSPITAL CORPORATION (US) | 2023-03-30 | — | — | WO | disclosed |