Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.72 |
| ▸ | HPGD | P15428 | 5/20 | 0.72 |
| ▸ | USP2 | O75604 | 1/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | MEN1 | O00255 | 10/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.67 |
| ▸ | GAA | P10253 | 10/20 | 0.66 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.66 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.66 |
| ▸ | GSK3A | P49840 | 1/20 | 0.66 |
| ▸ | GSK3B | P49841 | 1/20 | 0.66 |
| ▸ | GFER | P55789 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.61 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7509649 | 0.86 | KDM4E (0.65) | KDM4EALDH1A1HSD17B10HPGDUSP2 | |
| SCHEMBL7507701 | 0.84 | KDM4E (0.65) | KDM4EALDH1A1HSD17B10HPGDUSP2 | |
| SCHEMBL7137050 | 0.82 | ALDH1A1 (0.62) | KDM4EALDH1A1HSD17B10HPGDUSP2 | |
| SCHEMBL2396662 | 0.80 | KDM4E (0.72) | KDM4EALDH1A1HSD17B10HPGDMEN1 | |
| SCHEMBL6436600 | 0.79 | GAA (0.60) | KDM4EALDH1A1HSD17B10HPGDUSP2 | |
| SCHEMBL38662825 | 0.79 | KDM4E (0.63) | KDM4EALDH1A1HSD17B10HPGDMEN1 | |
| SCHEMBL30779659 | 0.79 | KDM4E (0.63) | KDM4EALDH1A1HSD17B10HPGDUSP2 | |
| SCHEMBL14247408 | 0.78 | RAB9A (0.72) | KDM4EALDH1A1HSD17B10HPGDUSP2 | |
| SCHEMBL4344048 | 0.77 | KDM4E (0.61) | KDM4EALDH1A1HSD17B10HPGDUSP2 | |
| SCHEMBL2730951 | 0.77 | KDM4E (0.61) | KDM4EALDH1A1HSD17B10HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304419-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2012-11-06 | — | — | US | disclosed |
| US-20100216746-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216746-A1 | CHEMICAL COMPOUNDS | SAMHD1, POLRMT, NUDT1 | KDM4E 1070/4885ALDH1A1 348/4885HSD17B10 761/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.