Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3026759 | 0.90 | KDM4E (0.62) | ALDH1A1HSD17B10TSHRCYP2C9KDM4E | |
| SCHEMBL7273568 | 0.88 | CYP2C9 (0.67) | ALDH1A1HSD17B10TSHRCYP2C9KDM4E | |
| SCHEMBL29808895 | 0.87 | TSHR (0.62) | ALDH1A1HSD17B10TSHRCYP2C9KDM4E | |
| SCHEMBL2563899 | 0.87 | TSHR (0.62) | ALDH1A1HSD17B10TSHRCYP2C9KDM4E | |
| SCHEMBL7266025 | 0.87 | ALDH1A1 (0.51) | ALDH1A1HSD17B10TSHRCYP2C9KDM4E | |
| SCHEMBL7265615 | 0.87 | ALDH1A1 (0.43) | ALDH1A1HSD17B10TSHRCYP2C9KDM4E | |
| SCHEMBL7272409 | 0.87 | ALDH1A1 (0.43) | ALDH1A1HSD17B10TSHRCYP2C9KDM4E | |
| SCHEMBL3016302 | 0.87 | ALDH1A1 (0.62) | ALDH1A1HSD17B10TSHRCYP2C9KDM4E | |
| SCHEMBL7267980 | 0.87 | PYGL (0.61) | CYP2C9KDM4ETBXA2RSLC6A3MAPT | |
| SCHEMBL10663333 | 0.86 | ALDH1A1 (0.43) | ALDH1A1HSD17B10TSHRCYP2C9KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4537898-A | WITH POLYOXYETHYLENE GLYCOL DERIVATIVES AS SOLUBILIZERS | BAYER AKTIENGESELLSCHAFT (DE) | 1985-08-27 | — | — | US | claimed |
| US-4510310-A | 1,4-Dihydro-2,6-dimethyl-4-(2'-chlorophenyl)-3,5-dicarboxylic acid,methyl or ethyl,trifluoroethyl ester | BAYER AKTIENGESELLSCHAFT (DE) | 1985-04-09 | — | — | US | claimed |
| US-20230210830-A1 | STABLE PHARMACEUTICAL COMPOSITION OF NIMODIPINE | ALKEM LABORATORIES LIMITED (IN) | 2023-07-06 | — | — | US | disclosed |
| CN-114516774-A | Preparation method of chiral bromo-1, 4-dihydropyridine compound | 中国科学院成都生物研究所 | 2022-05-20 | — | — | CN | disclosed |
| US-20100216784-A1 | Compounds for Inhibiting Beta-Amyloid Production and Methods of Identifying the Compounds | MULLAN MICHAEL J | 2010-08-26 | — | — | US | disclosed |
| US-20100215735-A1 | Compounds for Inhibiting Beta-Amyloid Production and Methods of Identifying the Compounds | MULLAN MICHAEL J | 2010-08-26 | — | — | US | disclosed |
| US-20080058330-A1 | Compounds and Combinations Thereof for Inhibiting Beta-Amyloid Production and Methods of Use Thereof | ROSKAMP RESEARCH LLC (US) | 2008-03-06 | — | — | US | disclosed |
| EP-1858325-A2 | COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF IDENTIFYING THE COMPOUNDS | Roskamp Research LLC (US) | 2007-11-28 | — | — | EP | disclosed |
| US-20070191409-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | ROSKAMP RESEARCH LLC | 2007-08-16 | — | — | US | disclosed |
| US-20070185130-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | ROSKAMP RESEARCH LLC | 2007-08-09 | — | — | US | disclosed |
| US-20070037855-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | ALZHEIMER'S INSTITUTE OF AMERICA, INC. | 2007-02-15 | — | — | US | disclosed |
| US-20060188938-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | ARCHER PHARMACEUTICALS, INC. | 2006-08-24 | — | — | US | disclosed |
| WO-2006074419-A2 | COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF IDENTIFYING THE COMPOUNDS | ROSKAMP RESEARCH LLC (US) | 2006-07-13 | — | — | WO | disclosed |
| CN-1089337-C | 1, 4-dihydropyridine derivatives | MERCIAN CORP (JP) | 2002-08-21 | — | — | CN | disclosed |
| EP-0779277-B1 | 1,4-DIHYDROPYRIDINE DERIVATIVE | MERCIAN CORP (JP) | 2002-07-10 | — | — | EP | disclosed |
| US-5760238-A | ANTIISCHEMIC AGENTS | MERCIAN CORPORATION (JP) | 1998-06-02 | — | — | US | disclosed |
| CN-1156450-A | 1,4-dihydropyridine derivatives | MERCIAN CORP (JP) | 1997-08-06 | — | — | CN | disclosed |
| US-4818766-A | ANTIARRHYTHMIA AGENTS, HYPOTENSIVE AGENTS, TREATMENT OF ANGINA | CIBA-GEIGY CORPORATION (US) | 1989-04-04 | — | — | US | disclosed |
| EP-0088903-B1 | 1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLIC ACID ESTER DERIVATIVES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1988-11-23 | — | — | EP | disclosed |
| EP-0094159-A1 | Dihydropyridine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1983-11-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058330-A1 | Compounds and Combinations Thereof for Inhibiting Beta-Amyloid Production and Methods of Use Thereof | APP, PSEN1, PSEN2 | ALDH1A1 3749/4885HSD17B10 3277/4885TSHR 4437/4885 |
| US-20070191409-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | APP, PSEN1, PSEN2 | ALDH1A1 3939/4885HSD17B10 2623/4885TSHR 4253/4885 |
| US-20070185130-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | APP, PSEN1, PSEN2 | ALDH1A1 3939/4885HSD17B10 2623/4885TSHR 4253/4885 |
| US-20070037855-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | APP, PSEN1, PSEN2 | ALDH1A1 3939/4885HSD17B10 2623/4885TSHR 4253/4885 |
| US-20100216784-A1 | Compounds for Inhibiting Beta-Amyloid Production and Methods of Identifying the Compounds | APP, PSEN1, PSEN2 | ALDH1A1 3939/4885HSD17B10 2623/4885TSHR 4253/4885 |
| US-20060188938-A1 | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds | APP, PSEN1, PSEN2 | ALDH1A1 3939/4885HSD17B10 2623/4885TSHR 4253/4885 |
| US-20230210830-A1 | STABLE PHARMACEUTICAL COMPOSITION OF NIMODIPINE | AQP1, CACNA1B, TRPV1 | ALDH1A1 2577/4885HSD17B10 1664/4885TSHR 4766/4885 |
| US-20100215735-A1 | Compounds for Inhibiting Beta-Amyloid Production and Methods of Identifying the Compounds | APP, PSEN1, PSEN2 | ALDH1A1 3939/4885HSD17B10 2623/4885TSHR 4253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.