Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.43 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.41 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28452694 | 1.00 | EGLN1 (0.47) | EGLN1KDM4ECYP1A2CYP3A4CYP2D6 | |
| SCHEMBL28441539 | 0.87 | DGAT1 (0.49) | EGLN1EGLN3DEGS1KMT2ANPC1 | |
| SCHEMBL28445193 | 0.85 | KDM4E (0.48) | EGLN1KDM4ECYP1A2LMNAMAPT | |
| SCHEMBL30345425 | 0.85 | KDM4E (0.48) | EGLN1KDM4ECYP1A2LMNAMAPT | |
| SCHEMBL28442664 | 0.84 | EGLN1 (0.50) | EGLN1KMT2ANPC1RAB9AKCNQ3 | |
| SCHEMBL30345507 | 0.84 | EGLN1 (0.50) | EGLN1KMT2ANPC1RAB9AKCNQ3 | |
| SCHEMBL28448361 | 0.83 | HDAC3 (0.50) | EGLN1EGLN3LMNA | |
| SCHEMBL30345395 | 0.83 | HDAC3 (0.50) | EGLN1EGLN3LMNA | |
| SCHEMBL28442587 | 0.81 | EGLN1 (0.64) | EGLN1KDM4EEGLN3MAPTKMT2A | |
| SCHEMBL30345459 | 0.81 | EGLN1 (0.64) | EGLN1KDM4EEGLN3MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111559982-B | 2- (2-substituted-4-hydroxypyrimidine-5-formamido) acetic acid compound and preparation method and application thereof | 天津市医药科学研究所 | 2023-04-07 | — | — | CN | claimed |
| CN-111559982-B | 2- (2-substituted-4-hydroxypyrimidine-5-formamido) acetic acid compound and preparation method and application thereof | 天津市医药科学研究所 | 2023-04-07 | — | — | CN | disclosed |