Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | DEGS1 | O15121 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28445193 | 1.00 | KDM4E (0.48) | KDM4EALDH1A1MAPTMEN1RECQL | |
| SCHEMBL28442664 | 0.88 | EGLN1 (0.50) | MEN1RECQLKMT2AEGLN1NPC1 | |
| SCHEMBL30345507 | 0.88 | EGLN1 (0.50) | MEN1RECQLKMT2AEGLN1NPC1 | |
| SCHEMBL28439104 | 0.85 | ITGB3 (0.53) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL30345412 | 0.85 | ITGB3 (0.53) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL28452694 | 0.85 | EGLN1 (0.47) | KDM4EALDH1A1MAPTKMT2AEGLN1 | |
| SCHEMBL30345442 | 0.85 | EGLN1 (0.47) | KDM4EALDH1A1MAPTKMT2AEGLN1 | |
| SCHEMBL28441539 | 0.84 | DGAT1 (0.49) | MEN1KMT2AEGLN1DEGS1NPC1 | |
| SCHEMBL28442506 | 0.83 | EGLN1 (0.66) | KDM4EALDH1A1MEN1KMT2AEGLN1 | |
| SCHEMBL30345405 | 0.83 | EGLN1 (0.66) | KDM4EALDH1A1MEN1KMT2AEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111559982-B | 2- (2-substituted-4-hydroxypyrimidine-5-formamido) acetic acid compound and preparation method and application thereof | 天津市医药科学研究所 | 2023-04-07 | — | — | CN | claimed |
| CN-111559982-B | 2- (2-substituted-4-hydroxypyrimidine-5-formamido) acetic acid compound and preparation method and application thereof | 天津市医药科学研究所 | 2023-04-07 | — | — | CN | disclosed |