SCHEMBL303457

SCHEMBL303457

CS(=O)(=O)c1nc2c(ccc3ccccc32)s1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
XIAP P98170 1/20 0.46
MEN1 O00255 6/20 0.42
KMT2A Q03164 6/20 0.42
POLB P06746 1/20 0.42
MAPT P10636 4/20 0.41
KDM4E B2RXH2 3/20 0.41
HTT P42858 2/20 0.41
HSD17B10 Q99714 2/20 0.41
NPC1 O15118 1/20 0.41
ALOX15 P16050 1/20 0.41
MAPK1 P28482 1/20 0.41
RAB9A P51151 1/20 0.41
ALDH1A1 P00352 4/20 0.40
HPGD P15428 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
LMNA P02545 3/20 0.38
AKR1B1 P15121 2/20 0.37
KEAP1 Q14145 1/20 0.37
PSMB8 P28062 1/20 0.37
PSMB5 P28074 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29843187 0.74 RAB9A (0.53) XIAPMEN1KMT2APOLBMAPT
SCHEMBL2170681 0.74 RAB9A (0.53) XIAPMEN1KMT2APOLBMAPT
SCHEMBL4139521 0.73 RAB9A (0.51) XIAPMEN1KMT2APOLBMAPT
SCHEMBL10946969 0.72 XIAP (0.50) XIAPMEN1KMT2APOLBMAPT
SCHEMBL9258930 0.72 SMN1; SMN2 (0.53) MEN1KMT2APOLBMAPTKDM4E
SCHEMBL1801464 0.72 ALDH1A1 (0.52) XIAPMEN1KMT2APOLBMAPT
Iodomethane SCHEMBL9193628 0.71 RAB9A (0.50) XIAPMEN1KMT2APOLBMAPT
SCHEMBL2754297 0.70 PSMB8 (0.70) MEN1KMT2AMAPTHTTHSD17B10
Bromide SCHEMBL4961408 0.70 ALDH1A1 (0.50) XIAPMEN1KMT2APOLBMAPT
SCHEMBL22457218 0.70 XIAP (0.48) XIAPMEN1KMT2APOLBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11332779-B2 Nucleic acid melting analysis with saturation dyes BIOFIRE DEFENSE, LLC (US) 2022-05-17 US disclosed
US-11091452-B2 Polymerizable compound, polymerizable composition, polymer, optically anisotropic body, and method for producing polymerizable compound ZEON CORPORATION (JP) 2021-08-17 US disclosed
US-20200248247-A1 Nucleic Acid Melting Analysis with Saturation Dyes UNIVERSITY OF UTAH 2020-08-06 US disclosed
EP-2826867-B1 Nucleic acid melting analysis with saturation dyes UNIV UTAH RES FOUND (US) 2020-06-03 EP disclosed
US-10655169-B2 Nucleic acid melting analysis with saturation dyes UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2020-05-19 US disclosed
US-20200048213-A1 POLYMERIZABLE COMPOUND, POLYMERIZABLE COMPOSITION, POLYMER, OPTICALLY ANISOTROPIC BODY, AND METHOD FOR PRODUCING POLYMERIZABLE COMPOUND ZEON CORPORATION (JP) 2020-02-13 US disclosed
US-10173992-B2 Polymerizable compound, polymerizable composition, polymer, optically anisotropic body, and method for producing polymerizable compound ZEON CORPORATION (JP) 2019-01-08 US disclosed
EP-2772552-B1 Amplicon melting analysis with saturation dyes UNIV UTAH RES FOUND (US) 2018-10-10 EP disclosed
EP-2871192-B1 POLYMERIZABLE COMPOUND, POLYMERIZABLE COMPOSITION, POLYMER, OPTICALLY ANISOTROPIC BODY, AND METHOD FOR PRODUCING POLYMERIZABLE COMPOUND ZEON CORP (JP) 2018-06-20 EP disclosed
US-20180066137-A1 AMPLICON MELTING ANALYSIS WITH SATURATION DYES WITTWER CARL T (US) 2018-03-08 US disclosed
US-20100041044-A1 Amplifying the target nucleic acid with primers in the presence of a double-stranded DNA binding dye; monitoring fluorescence of the dye; melting curve is generated for the target nucleic acid by measuring fluorescence from the dsDNA binding dye as the mixture is heated. BIOFIRE DIAGNOSTICS, INC. 2010-02-18 US disclosed
US-7582429-B2 Polymerase chain reaction analysis by mixing a dsDNA binding dye with a sample of target nucleic acid and primers configured for amplifying; melting the amplified target nucleic acid to generate a melting curve; plotting; repeating; comparison; melting curve difference for each target nucleic acid UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2009-09-01 US disclosed
US-20090117553-A1 NUCLEIC ACID MELTING ANALYSIS WITH SATURATION DYES UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2009-05-07 US disclosed
US-7456281-B2 Nucleic acid melting analysis with saturation dyes IDAHO TECHNOLOGY, INC. 2008-11-25 US disclosed
US-7387887-B2 Nucleic acid melting analysis with saturation dyes UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2008-06-17 US disclosed
EP-1774047-A2 NUCLEIC ACID MELTING ANALYSIS WITH SATURATION DYES University of Utah Research Foundation (US) 2007-04-18 EP disclosed
US-20070020672-A1 Nucleic acid melting analysis with saturation dyes IDAHO TECHNOLOGY, INC. (US) 2007-01-25 US disclosed
WO-2006121423-A2 NUCLEIC ACID MELTING ANALYSIS WITH SATURATION DYES UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2006-11-16 WO disclosed
US-20060019253-A1 Polymerase chain reaction analysis by mixing a dsDNA binding dye with a sample of target nucleic acid and primers configured for amplifying; melting the amplified target nucleic acid to generate a melting curve; plotting; repeating; comparison; melting curve difference for each target nucleic acid NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2006-01-26 US disclosed
US-20050233335-A1 standard PCR solution with additional saturating double-stranded (ds) DNA binding dye; fluorescence; cyanine dyes UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2005-10-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10173992-B2 Polymerizable compound, polymerizable composition, polymer, optically anisotropic body, and method for producing polymerizable compound PYM1, C5, C1S XIAP 3337/4885MEN1 2592/4885KMT2A 1709/4885
US-20200048213-A1 POLYMERIZABLE COMPOUND, POLYMERIZABLE COMPOSITION, POLYMER, OPTICALLY ANISOTROPIC BODY, AND METHOD FOR PRODUCING POLYMERIZABLE COMPOUND PDE8A, MAPT, PLK4 XIAP 4321/4885MEN1 1191/4885KMT2A 3296/4885
US-11091452-B2 Polymerizable compound, polymerizable composition, polymer, optically anisotropic body, and method for producing polymerizable compound PDE8A, MAPT, PLK4 XIAP 4321/4885MEN1 1191/4885KMT2A 3296/4885
US-20060019253-A1 Polymerase chain reaction analysis by mixing a dsDNA binding dye with a sample of target nucleic acid and primers configured for amplifying; melting the amplified target nucleic acid to generate a melting curve; plotting; repeating; comparison; melting curve difference for each target nucleic acid POLL, DNA2, POLRMT XIAP 3158/4885MEN1 3232/4885KMT2A 2584/4885
US-20070020672-A1 Nucleic acid melting analysis with saturation dyes DNA2, POLL, POLRMT XIAP 4766/4885MEN1 3562/4885KMT2A 2946/4885
US-20050233335-A1 standard PCR solution with additional saturating double-stranded (ds) DNA binding dye; fluorescence; cyanine dyes DDB1, POLL, POLRMT XIAP 4742/4885MEN1 2024/4885KMT2A 3651/4885
US-20180066137-A1 AMPLICON MELTING ANALYSIS WITH SATURATION DYES NOP2, POLL, DNA2 XIAP 4837/4885MEN1 3715/4885KMT2A 1178/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.